Tryptophan

Tryptophan

SCHEMBL3831274

NC=O.N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O

nearest known ligand 0.89

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.89
MAPT P10636 3/20 0.89
KMT2A Q03164 3/20 0.89
LMNA P02545 2/20 0.89
TSHR P16473 2/20 0.89
BLM P54132 2/20 0.89
PMP22 Q01453 2/20 0.89
MEN1 O00255 2/20 0.89
MPO P05164 1/20 0.89
HIF1A Q16665 1/20 0.89
SMN1; SMN2 Q16637 1/20 0.63
APAF1 O14727 1/20 0.62
POLB P06746 1/20 0.62
RECQL P46063 1/20 0.62
L3MBTL1 Q9Y468 1/20 0.62
HTR2A P28223 3/20 0.61
HTR1A P08908 2/20 0.61
HTR2C P28335 2/20 0.61
SLC6A4 P31645 2/20 0.61
HTR7 P34969 2/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
D-Tryptophan SCHEMBL3829872 1.00 KDM4E (0.89) KDM4EMAPTKMT2ALMNATSHR
Dl-Tryptophan SCHEMBL27327550 0.94 KDM4E (0.89) KDM4EMAPTKMT2ALMNATSHR
Dl-Tryptophan SCHEMBL27840618 0.94 KDM4E (0.89) KDM4EMAPTKMT2ALMNATSHR
Dl-Tryptophan SCHEMBL7327 0.94 KMT2A (1.00) KDM4EMAPTKMT2ALMNATSHR
Tryptophan SCHEMBL475350 0.94 KMT2A (1.00) KDM4EMAPTKMT2ALMNATSHR
Tryptophan SCHEMBL23141133 0.94 KMT2A (1.00) KDM4EMAPTKMT2ALMNATSHR
Dl-Tryptophan SCHEMBL4732052 0.94 KMT2A (1.00) KDM4EMAPTKMT2ALMNATSHR
Dl-Tryptophan SCHEMBL475349 0.94 KMT2A (1.00) KDM4EMAPTKMT2ALMNATSHR
Dl-Tryptophan SCHEMBL289042 0.94 KMT2A (1.00) KDM4EMAPTKMT2ALMNATSHR
Tryptophan SCHEMBL4732053 0.94 KMT2A (1.00) KDM4EMAPTKMT2ALMNATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-59005113-A None JP disclosed
CN-109468304-B Hydantoinase mutants 赢创运营有限公司 2022-04-19 CN disclosed
US-10822627-B2 Mutants of hydantoinase EVONIK OPERATIONS GMBH (DE) 2020-11-03 US disclosed
US-20180237814-A1 MUTANTS OF HYDANTOINASE EVONIK TECHNOCHEMIE GMBH (DE) 2018-08-23 US disclosed
US-9957536-B2 Mutants of hydantoinase EVONIK TECHNOCHEMIE GMBH (DE) 2018-05-01 US disclosed
EP-2780451-B1 MUTANTS OF HYDANTOINASE EVONIK TECHNOCHEMIE GMBH (DE) 2017-09-20 EP disclosed
US-20150056667-A1 MUTANTS OF HYDANTOINASE EVONIK OPERATIONS GMBH (DE) 2015-02-26 US disclosed
EP-2780451-A1 MUTANTS OF HYDANTOINASE Evonik Industries AG (DE) 2014-09-24 EP disclosed
WO-2013072486-A1 MUTANTS OF HYDANTOINASE EVONIK INDUSTRIES AG (DE) 2013-05-23 WO disclosed
EP-1070132-B1 RECOMBINANT L-N-CARBAMOYLASE DERIVED FROM ARTHROBACTER AURESCENS, AND A METHOD FOR PRODUCING L-AMINO ACIDS BY USING THE SAME EVONIK DEGUSSA GMBH (DE) 2009-09-23 EP disclosed
US-20040082079-A1 Low affinity screening method GRAFFINITY PHARMACEUTICALS AG. (DE) 2004-04-29 US disclosed
EP-1360489-A1 LOW AFFINITY SCREENING METHOD Graffinity Pharmaceuticals Aktiengesellschaft (DE) 2003-11-12 EP disclosed
WO-2002063299-A1 LOW AFFINITY SCREENING METHOD GRAFFINITY PHARMACEUTICALS AG (DE) 2002-08-15 WO disclosed
EP-1070132-A2 RECOMBINANT L-N-CARBAMOYLASE DERIVED FROM $i(ARTHROBACTER AURESCENS), AND A METHOD FOR PRODUCING L-AMINO ACIDS BY USING THE SAME Degussa-Hüls Aktiengesellschaft (DE) 2001-01-24 EP disclosed
WO-1999051722-A2 RECOMBINANT L-N-CARBAMOYLASE DERIVED FROM ARTHROBACTER AURESCENS, AND A METHOD FOR PRODUCING L-AMINO ACIDS BY USING THE SAME Degussa-Hüls Aktiengesellschaft (DE) 1999-10-14 WO disclosed
EP-0377083-B1 PROCESS TO PRODUCE L-ALPHA-AMINO ACIDS RÜTGERSWERKE AKTIENGESELLSCHAFT (DE) 1993-09-22 EP disclosed
EP-0377083-A1 Process to produce L-alpha-amino acids RÜTGERSWERKE AKTIENGESELLSCHAFT (DE) 1990-07-11 EP disclosed
JP-S595113-A PREPARATION OF AMINO ACID INJECTION CONTAINING REDUCING SUGAR MOHAN YAKUHIN KENKYUSHO:KK 1984-01-12 JP disclosed