Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.51 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 7/20 | 0.50 |
| ▸ | RAF1 | P04049 | 4/20 | 0.45 |
| ▸ | ARAF | P10398 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 5/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.40 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.40 |
| ▸ | BLK | P51451 | 1/20 | 0.40 |
| ▸ | BMX | P51813 | 1/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3831491 | 0.90 | KDR (0.47) | KDRFGFR1BRAFRAF1ARAF | |
| SCHEMBL3833067 | 0.86 | KDR (0.45) | KDRBRAFRAF1ABL1SRC | |
| SCHEMBL5105268 | 0.86 | KDR (0.52) | KDRFGFR1BRAFRAF1ARAF | |
| SCHEMBL3242770 | 0.83 | KDR (0.45) | KDRFGFR1BRAFRAF1ARAF | |
| SCHEMBL3836297 | 0.82 | RIPK1 (0.40) | KDRFGFR1BRAFRAF1ABL1 | |
| SCHEMBL3834781 | 0.82 | RIPK1 (0.45) | KDRFGFR1BRAFRAF1ABL1 | |
| SCHEMBL3833227 | 0.82 | RET (0.40) | KDRBRAFRAF1ARAFABL1 | |
| SCHEMBL3834284 | 0.81 | RET (0.43) | KDRFGFR1BRAFRAF1ABL1 | |
| SCHEMBL3834263 | 0.81 | RIPK1 (0.56) | KDRFGFR1ABL1SRCFYN | |
| SCHEMBL3832628 | 0.81 | EPHX2 (0.53) | KDRBRAFRAF1ARAFMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682548-B1 | PYRIDOPYRIMIDINONES FOR THE TREATMENT OF CANCER DISEASES | MERCK PATENT GMBH (DE) | 2009-09-23 | — | — | EP | claimed |
| US-7547695-B2 | Pyridopyrimidinones | MERCK PATENT GMBH (DE) | 2009-06-16 | — | — | US | claimed |
| US-20070099910-A1 | Pyridopyrimidinones | MERCK PATENT GMBH (DE) | 2007-05-03 | — | — | US | claimed |
| US-7547695-B2 | Pyridopyrimidinones | MERCK PATENT GMBH (DE) | 2009-06-16 | — | — | US | disclosed |
| US-20070099910-A1 | Pyridopyrimidinones | MERCK PATENT GMBH (DE) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099910-A1 | Pyridopyrimidinones | TIE1, FER, FLT1 | KDR 8/4885FGFR1 32/4885BRAF 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.