Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.62 |
| ▸ | ESR1 | P03372 | 2/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.53 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.45 |
| ▸ | NQO2 | P16083 | 2/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3832249 | 1.00 | PTGS1 (0.62) | PTGS1ESR1ESR2CYP1B1PTGS2 | |
| SCHEMBL3832255 | 1.00 | PTGS1 (0.62) | PTGS1ESR1ESR2CYP1B1PTGS2 | |
| SCHEMBL3827498 | 0.92 | PTGS1 (0.58) | PTGS1ESR1ESR2CYP1B1PTGS2 | |
| SCHEMBL3827490 | 0.92 | PTGS1 (0.58) | PTGS1ESR1ESR2CYP1B1PTGS2 | |
| SCHEMBL3827495 | 0.92 | PTGS1 (0.58) | PTGS1ESR1ESR2CYP1B1PTGS2 | |
| SCHEMBL11835186 | 0.90 | PTGS1 (0.69) | PTGS1ESR1ESR2PTGS2NQO2 | |
| SCHEMBL7803180 | 0.89 | ESR1 (0.64) | PTGS1ESR1ESR2PTGS2MAPT | |
| SCHEMBL726320 | 0.85 | ESR1 (0.58) | PTGS1ESR1ESR2PTGS2NQO2 | |
| SCHEMBL1225178 | 0.85 | ESR1 (0.58) | PTGS1ESR1ESR2PTGS2NQO2 | |
| SCHEMBL726321 | 0.85 | ESR1 (0.58) | PTGS1ESR1ESR2PTGS2NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090312310-A1 | Imidazothiazole derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-12-17 | — | — | US | disclosed |
| EP-2103619-A1 | IMIDAZOTHIAZOLE DERIVATIVES | Daiichi Sankyo Company, Limited (JP) | 2009-09-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312310-A1 | Imidazothiazole derivatives | TP53, MDM2, TP53BP1 | PTGS1 2077/4885ESR1 1616/4885ESR2 1548/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.