Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | ITGB2 | P05107 | 3/20 | 0.32 |
| ▸ | ICAM1 | P05362 | 3/20 | 0.32 |
| ▸ | ITGAL | P20701 | 3/20 | 0.32 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 2/20 | 0.30 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3832297 | 1.00 | NPC1 (0.38) | NPC1RAB9AMEN1KMT2AITGB2 | |
| SCHEMBL3833362 | 0.82 | MEN1 (0.39) | MEN1KMT2ARXFP1CNR1TP53 | |
| SCHEMBL3833365 | 0.82 | MEN1 (0.39) | MEN1KMT2ARXFP1CNR1TP53 | |
| SCHEMBL3830291 | 0.77 | TP53 (0.36) | KDM4EL3MBTL1MAPTTP53MDM2 | |
| SCHEMBL3830287 | 0.77 | TP53 (0.36) | KDM4EL3MBTL1MAPTTP53MDM2 | |
| SCHEMBL3828319 | 0.75 | HSD11B1 (0.49) | MEN1KMT2AALDH1A1MAPTTP53 | |
| SCHEMBL3828314 | 0.75 | HSD11B1 (0.49) | MEN1KMT2AALDH1A1MAPTTP53 | |
| SCHEMBL3832815 | 0.72 | GSK3A (0.38) | NPC1RAB9AMEN1KMT2ACNR1 | |
| SCHEMBL3832816 | 0.72 | GSK3A (0.38) | NPC1RAB9AMEN1KMT2ACNR1 | |
| SCHEMBL3833465 | 0.68 | NPC1 (0.37) | NPC1RAB9AMEN1KMT2ARXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090312310-A1 | Imidazothiazole derivatives | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-12-17 | — | — | US | disclosed |
| EP-2103619-A1 | IMIDAZOTHIAZOLE DERIVATIVES | Daiichi Sankyo Company, Limited (JP) | 2009-09-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090312310-A1 | Imidazothiazole derivatives | TP53, MDM2, TP53BP1 | NPC1 4744/4885RAB9A 3326/4885MEN1 2718/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.