Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Naproxen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 3/20 | 0.94 |
| ▸ | PTGS1 known ✓ | P23219 | 3/20 | 0.94 |
| ▸ | AKR1C3 | P42330 | 11/20 | 0.94 |
| ▸ | AKR1C2 | P52895 | 11/20 | 0.94 |
| ▸ | TSHR | P16473 | 2/20 | 0.94 |
| ▸ | CDC42 | P60953 | 1/20 | 0.94 |
| ▸ | RAC1 | P63000 | 1/20 | 0.94 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.94 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.94 |
| ▸ | LMNA | P02545 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.61 |
| ▸ | APP | P05067 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naproxen SCHEMBL29181186 | 0.98 | AKR1C3 (0.97) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL7362 | 0.98 | AKR1C3 (0.97) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL28999051 | 0.98 | AKR1C3 (0.97) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL3187018 | 0.98 | AKR1C3 (0.97) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL8469467 | 0.98 | AKR1C3 (0.97) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL2472354 | 0.98 | AKR1C3 (0.97) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL3046 | 0.97 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL10029028 | 0.97 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL215236 | 0.97 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL42434 | 0.97 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1684728-B1 | NON-EFFERVESCENT FORM OF SODIUM NAPROXEN COMPRISING I.A. SODIUM HYDROGEN CARBONATE | BAYER CONSUMER CARE AG (CH) | 2009-09-16 | — | — | EP | disclosed |
| US-20070134317-A1 | Non-effervescent form of sodium naproxen comprising i.a. sodium hydrogen carbonate | BAYER CONSUMER CARE AG | 2007-06-14 | — | — | US | disclosed |
| EP-1684728-A1 | NON-EFFERVESCENT FORM OF SODIUM NAPROXEN COMPRISING I.A. SODIUM HYDROGEN CARBONATE | Bayer Consumer Care AG (CH) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005041938-A1 | NON-EFFERVESCENT FORM OF SODIUM NAPROXEN COMPRISING I.A. SODIUM HYDROGEN CARBONATE | BAYER CONSUMER CARE AG (CH) | 2005-05-12 | — | — | WO | disclosed |