Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Naproxen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 known ✓ | P35354 | 3/20 | 0.97 |
| ▸ | PTGS1 known ✓ | P23219 | 3/20 | 0.97 |
| ▸ | AKR1C3 | P42330 | 11/20 | 0.97 |
| ▸ | AKR1C2 | P52895 | 11/20 | 0.97 |
| ▸ | TSHR | P16473 | 2/20 | 0.97 |
| ▸ | CDC42 | P60953 | 1/20 | 0.97 |
| ▸ | RAC1 | P63000 | 1/20 | 0.97 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.97 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.97 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.68 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.68 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.63 |
| ▸ | APP | P05067 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Naproxen SCHEMBL3187018 | 1.00 | AKR1C3 (0.97) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL29181186 | 1.00 | AKR1C3 (0.97) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL3832769 | 0.98 | AKR1C3 (0.94) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL28834409 | 0.98 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL3046 | 0.98 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL29350704 | 0.98 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL29360045 | 0.98 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL10029028 | 0.98 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL215236 | 0.98 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR | |
| Naproxen SCHEMBL42434 | 0.98 | AKR1C3 (1.00) | AKR1C3AKR1C2PTGS2PTGS1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999029651-A1 | SODIUM (S)-2-(6-METHOXY-2-NAPHTHYL)-PROPIONATE MONOHYDRATE | ALBEMARLE CORPORATION (US) | 1999-06-17 | — | — | WO | claimed |
| US-5874614-A | LARGER PARTICLE SIZES; SIMPLIFIED HANDLING | ALBEMARLE CORPORATION (US) | 1999-02-23 | — | — | US | claimed |
| CN-110545850-A | Releasable conjugates | QUIAPEG PHARMACEUTICALS AB | 2019-12-06 | — | — | CN | disclosed |
| CN-102276447-B | Naproxen hydrate crystal, preparation method thereof and medicinal composition containing naproxen hydrate crystal and sumatriptan | HAINAN JINRUI PHARMACEUTICAL | 2013-11-20 | — | — | CN | disclosed |
| CN-102276447-B | Naproxen hydrate crystal, preparation method thereof and medicinal composition containing naproxen hydrate crystal and sumatriptan | HAINAN JINRUI PHARMACEUTICAL | 2013-11-20 | — | — | CN | disclosed |
| CN-102276447-A | Naproxen hydrate crystal, preparation method thereof and medicinal composition containing naproxen hydrate crystal and sumatriptan | — | 2011-12-14 | — | — | CN | disclosed |
| CN-102276447-A | Naproxen hydrate crystal, preparation method thereof and medicinal composition containing naproxen hydrate crystal and sumatriptan | — | 2011-12-14 | — | — | CN | disclosed |
| CN-101522175-A | Solubilized non-steroidal anti-inflammatory drugs | LOSAN PHARMA GMBH (DE) | 2009-09-02 | — | — | CN | disclosed |
| WO-1999029651-A1 | SODIUM (S)-2-(6-METHOXY-2-NAPHTHYL)-PROPIONATE MONOHYDRATE | ALBEMARLE CORPORATION (US) | 1999-06-17 | — | — | WO | disclosed |
| WO-1999029651-A1 | SODIUM (S)-2-(6-METHOXY-2-NAPHTHYL)-PROPIONATE MONOHYDRATE | ALBEMARLE CORPORATION (US) | 1999-06-17 | — | — | WO | disclosed |
| US-5874614-A | LARGER PARTICLE SIZES; SIMPLIFIED HANDLING | ALBEMARLE CORPORATION (US) | 1999-02-23 | — | — | US | disclosed |
| US-5874614-A | LARGER PARTICLE SIZES; SIMPLIFIED HANDLING | ALBEMARLE CORPORATION (US) | 1999-02-23 | — | — | US | disclosed |
| US-5874614-A | LARGER PARTICLE SIZES; SIMPLIFIED HANDLING | ALBEMARLE CORPORATION (US) | 1999-02-23 | — | — | US | disclosed |