Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3077212 | 0.77 | ALDH1A1 (0.44) | ALDH1A1LMNAHPGDKDM4EMEN1 | |
| SCHEMBL3074985 | 0.74 | ALDH1A1 (0.37) | ALDH1A1LMNAHPGDKDM4EMEN1 | |
| SCHEMBL14137780 | 0.74 | MEN1 (0.38) | ALDH1A1LMNAHPGDKDM4EMEN1 | |
| SCHEMBL3074711 | 0.74 | MEN1 (0.38) | ALDH1A1LMNAHPGDKDM4EMEN1 | |
| SCHEMBL9216566 | 0.74 | ALDH1A1 (0.37) | ALDH1A1LMNAHPGDKDM4EMEN1 | |
| SCHEMBL3965427 | 0.74 | ALDH1A1 (0.34) | ALDH1A1LMNAHPGDKDM4E | |
| SCHEMBL6105672 | 0.72 | ALDH1A1 (0.37) | ALDH1A1LMNAHPGDKDM4ERYR2 | |
| SCHEMBL10465670 | 0.71 | NOX1 (0.37) | ALDH1A1LMNAHPGDKDM4EMEN1 | |
| SCHEMBL9008647 | 0.71 | ALDH1A1 (0.39) | ALDH1A1LMNAHPGDKDM4EMEN1 | |
| SCHEMBL7822980 | 0.69 | KDM4E (0.34) | ALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1940844-B1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2009-09-30 | — | — | EP | disclosed |