Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F11 | P03951 | 20/20 | 0.46 |
| ▸ | F10 | P00742 | 4/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 4/20 | 0.44 |
| ▸ | PLG | P00747 | 3/20 | 0.44 |
| ▸ | PLAT | P00750 | 3/20 | 0.44 |
| ▸ | PROC | P04070 | 1/20 | 0.38 |
| ▸ | F9 | P00740 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4707091 | 0.85 | F11 (0.53) | F11F10KLKB1PLGPLAT | |
| SCHEMBL3834387 | 0.85 | F11 (0.46) | F11F10KLKB1PLGPLAT | |
| SCHEMBL3608267 | 0.79 | F11 (0.70) | F11F10KLKB1PLGPLAT | |
| SCHEMBL16938793 | 0.79 | F11 (0.51) | F11F10KLKB1PLGPLAT | |
| SCHEMBL3613011 | 0.79 | F11 (0.70) | F11F10KLKB1PLGPLAT | |
| SCHEMBL3633162 | 0.78 | F11 (0.46) | F11F10KLKB1PLGPLAT | |
| SCHEMBL3634639 | 0.77 | F11 (0.51) | F11F10KLKB1PLGPLAT | |
| SCHEMBL3633421 | 0.74 | F11 (0.65) | F11F10KLKB1PLGPLAT | |
| SCHEMBL3634024 | 0.74 | F11 (0.39) | F11F10KLKB1PLGPLAT | |
| SCHEMBL3634339 | 0.72 | MAPT (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2102189-A2 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | Brystol-Myers Squibb Company (US) | 2009-09-23 | — | — | EP | disclosed |
| WO-2008076805-A2 | ARYLPROPIONAMIDE, ARYLACRYLAMIDE, ARYLPROPYNAMIDE, OR ARYLMETHYLUREA ANALOGS AS FACTOR XIA INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-06-26 | — | — | WO | disclosed |