Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | IDH2 | P48735 | 5/20 | 0.40 |
| ▸ | LCK | P06239 | 4/20 | 0.40 |
| ▸ | FLT1 | P17948 | 7/20 | 0.40 |
| ▸ | KDR | P35968 | 5/20 | 0.40 |
| ▸ | TEK | Q02763 | 5/20 | 0.40 |
| ▸ | CSF1R | P07333 | 4/20 | 0.40 |
| ▸ | FLT4 | P35916 | 4/20 | 0.40 |
| ▸ | KIT | P10721 | 4/20 | 0.40 |
| ▸ | GSK3A | P49840 | 3/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | AURKA | O14965 | 3/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.40 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | PLK4 | O00444 | 2/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3834284 | 0.91 | RET (0.43) | RETIDH2LCKFLT1KDR | |
| SCHEMBL3833227 | 0.90 | RET (0.40) | RETLCKFLT1KDRCSF1R | |
| SCHEMBL3829680 | 0.84 | RET (0.50) | RETLCKFLT1KDRTEK | |
| SCHEMBL3829906 | 0.83 | RET (0.47) | RETLCKFLT1KDRTEK | |
| SCHEMBL3837304 | 0.81 | TYRO3 (0.38) | RETLCKKDRTEKKIT | |
| SCHEMBL3836413 | 0.81 | FLT1 (0.41) | RETLCKFLT1KDRTEK | |
| SCHEMBL3831528 | 0.81 | RET (0.61) | RETLCKFLT1KDRTEK | |
| SCHEMBL3831491 | 0.81 | KDR (0.47) | RETFLT1KDRFLT4AURKA | |
| SCHEMBL3235223 | 0.81 | KCNH2 (0.41) | RETIDH2LCKFLT1KDR | |
| SCHEMBL3835924 | 0.81 | BRAF (0.40) | RETLCKFLT1KDRTEK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682548-B1 | PYRIDOPYRIMIDINONES FOR THE TREATMENT OF CANCER DISEASES | MERCK PATENT GMBH (DE) | 2009-09-23 | — | — | EP | claimed |
| US-7547695-B2 | Pyridopyrimidinones | MERCK PATENT GMBH (DE) | 2009-06-16 | — | — | US | claimed |
| US-20070099910-A1 | Pyridopyrimidinones | MERCK PATENT GMBH (DE) | 2007-05-03 | — | — | US | claimed |
| US-7547695-B2 | Pyridopyrimidinones | MERCK PATENT GMBH (DE) | 2009-06-16 | — | — | US | disclosed |
| US-20070099910-A1 | Pyridopyrimidinones | MERCK PATENT GMBH (DE) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099910-A1 | Pyridopyrimidinones | TIE1, FER, FLT1 | RET 6/4885IDH2 247/4885LCK 83/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.