Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | FLT1 | P17948 | 6/20 | 0.48 |
| ▸ | TEK | Q02763 | 5/20 | 0.48 |
| ▸ | KDR | P35968 | 4/20 | 0.48 |
| ▸ | RAF1 | P04049 | 8/20 | 0.47 |
| ▸ | CSF1R | P07333 | 3/20 | 0.46 |
| ▸ | KIT | P10721 | 3/20 | 0.46 |
| ▸ | FLT4 | P35916 | 3/20 | 0.46 |
| ▸ | AURKA | O14965 | 3/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3829906 | 0.89 | RET (0.47) | RETBRAFFLT1TEKKDR | |
| SCHEMBL3833067 | 0.88 | KDR (0.45) | RETBRAFFLT1TEKKDR | |
| SCHEMBL3831528 | 0.88 | RET (0.61) | RETFLT1TEKKDRCSF1R | |
| SCHEMBL3837284 | 0.87 | RET (0.44) | RETBRAFFLT1TEKKDR | |
| SCHEMBL3837288 | 0.87 | ALDH1A1 (0.45) | RETBRAFFLT1TEKKDR | |
| SCHEMBL3835826 | 0.87 | KDR (0.51) | RETFLT1TEKKDRCSF1R | |
| SCHEMBL3834284 | 0.85 | RET (0.43) | RETBRAFFLT1TEKKDR | |
| SCHEMBL3836431 | 0.85 | TEK (0.47) | RETBRAFFLT1TEKKDR | |
| SCHEMBL2336170 | 0.84 | RET (0.48) | RETFLT1TEKKDRCSF1R | |
| SCHEMBL3833243 | 0.84 | RET (0.42) | RETBRAFFLT1TEKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682548-B1 | PYRIDOPYRIMIDINONES FOR THE TREATMENT OF CANCER DISEASES | MERCK PATENT GMBH (DE) | 2009-09-23 | — | — | EP | claimed |
| US-7547695-B2 | Pyridopyrimidinones | MERCK PATENT GMBH (DE) | 2009-06-16 | — | — | US | claimed |
| US-20070099910-A1 | Pyridopyrimidinones | MERCK PATENT GMBH (DE) | 2007-05-03 | — | — | US | claimed |
| US-7547695-B2 | Pyridopyrimidinones | MERCK PATENT GMBH (DE) | 2009-06-16 | — | — | US | disclosed |
| US-20070099910-A1 | Pyridopyrimidinones | MERCK PATENT GMBH (DE) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099910-A1 | Pyridopyrimidinones | TIE1, FER, FLT1 | RET 6/4885BRAF 28/4885FLT1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.