Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 1/20 | 0.55 |
| ▸ | USP7 | Q93009 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PLAT | P00750 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2901525 | 0.85 | POLB (0.60) | HTR4USP7HTTPOLBCASP3 | |
| Hydrochloric Acid SCHEMBL3828123 | 0.84 | HTR4 (0.59) | HTR4USP7HTTPOLBCASP3 | |
| SCHEMBL13135846 | 0.84 | USP7 (0.55) | HTR4USP7HTTPOLBCASP3 | |
| SCHEMBL13135845 | 0.84 | NPC1 (0.64) | HTR4USP7HTTPOLBCASP3 | |
| SCHEMBL2896878 | 0.82 | USP7 (0.54) | HTR4USP7HTTPOLBCASP3 | |
| SCHEMBL2901623 | 0.82 | USP7 (0.54) | HTR4USP7HTTPOLBCASP3 | |
| SCHEMBL14276125 | 0.82 | KMT2A (0.55) | HTR4USP7HTTPOLBCASP3 | |
| SCHEMBL13135847 | 0.81 | USP7 (0.53) | HTR4USP7HTTPOLBCASP3 | |
| SCHEMBL2900452 | 0.81 | NPC1 (0.57) | HTR4USP7HTTPOLBCASP3 | |
| Hydrochloric Acid SCHEMBL3830015 | 0.81 | USP7 (0.53) | HTR4USP7HTTPOLBCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1585515-B1 | PIPERIDINE AND PYRROLIDINE DERIVATIVES AS ANTAGONISTS OF HISTAMINE H3 RECEPTOR | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-09-16 | — | — | EP | claimed |
| EP-1585515-B1 | PIPERIDINE AND PYRROLIDINE DERIVATIVES AS ANTAGONISTS OF HISTAMINE H3 RECEPTOR | HIGH POINT PHARMACEUTICALS LLC (US) | 2009-09-16 | — | — | EP | disclosed |