Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.38 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.38 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1990596 | 0.77 | NPC1 (0.49) | HPGDKDM4EALDH1A1SMN1; SMN2EPHX2 | |
| SCHEMBL1115073 | 0.74 | NPC1 (0.47) | HPGDKDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL4778685 | 0.74 | NPC1 (0.51) | HPGDKDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL14911305 | 0.73 | NPC1 (0.54) | HPGDKDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL6766655 | 0.72 | EPHX2 (0.47) | HPGDKDM4EALDH1A1SMN1; SMN2EPHX2 | |
| SCHEMBL27647235 | 0.70 | CYP2C19 (0.46) | KDM4EALDH1A1 | |
| SCHEMBL3705934 | 0.70 | HTT (0.63) | HSD17B10HPGDKDM4EALDH1A1TSHR | |
| SCHEMBL6763548 | 0.69 | PYGL (0.49) | — | |
| SCHEMBL6763550 | 0.69 | PYGL (0.49) | — | |
| SCHEMBL4904390 | 0.69 | GAA (0.39) | KDM4EALDH1A1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2106396-A2 | CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | AstraZeneca AB (SE) | 2009-10-07 | — | — | EP | disclosed |
| WO-2008084223-A2 | CHEMICAL COMPOUNDS 637: PYRIDOPYRIMIDINEDIONES AS PDE4 INHIBITORS | ASTRAZENECA AB (SE) | 2008-07-17 | — | — | WO | disclosed |