Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | GRN | P28799 | 1/20 | 0.47 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | USP1 | O94782 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14638384 | 0.84 | LMNA (0.56) | LMNAKMT2AGRNSORT1KDM4E | |
| SCHEMBL14410518 | 0.81 | LMNA (0.54) | LMNAKMT2AGRNSORT1KDM4E | |
| SCHEMBL17819775 | 0.81 | KDM4E (0.60) | LMNAKMT2AGRNSORT1KDM4E | |
| SCHEMBL1599534 | 0.81 | LMNA (0.56) | LMNAKMT2AGRNSORT1KDM4E | |
| SCHEMBL29691288 | 0.81 | LMNA (0.53) | LMNAKMT2AGRNSORT1KDM4E | |
| SCHEMBL18338880 | 0.81 | LMNA (0.53) | LMNAKMT2AGRNSORT1KDM4E | |
| SCHEMBL30046017 | 0.81 | LMNA (0.56) | LMNAKMT2AGRNSORT1KDM4E | |
| SCHEMBL17159482 | 0.81 | LMNA (0.53) | LMNAKMT2AGRNSORT1KDM4E | |
| SCHEMBL4178530 | 0.81 | LMNA (0.53) | LMNAKMT2AGRNSORT1KDM4E | |
| SCHEMBL951325 | 0.81 | LMNA (0.53) | LMNAKMT2AGRNSORT1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091937-A2 | SUBSTITUTED IMIDAZOLES AS BOMBESIN RECEPTOR SUBTYPE-3 MODULATORS | Merck & Co., Inc. (US) | 2009-08-26 | — | — | EP | disclosed |
| WO-2008051406-A2 | SUBSTITUTED IMIDAZOLES AS BOMBESIN RECEPTOR SUBTYPE-3 MODULATORS | MERCK & CO., INC. (US) | 2008-05-02 | — | — | WO | disclosed |