Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.36 |
| ▸ | BAD | Q92934 | 1/20 | 0.36 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5184055 | 0.82 | AOC3 (0.42) | HPGDTDP1FFAR1AOC3KMT2A | |
| SCHEMBL2089224 | 0.82 | AOC3 (0.42) | HPGDTDP1FFAR1AOC3KMT2A | |
| SCHEMBL756439 | 0.82 | AOC3 (0.42) | HPGDTDP1FFAR1AOC3KMT2A | |
| Hydrochloric Acid SCHEMBL18920497 | 0.80 | AOC3 (0.41) | HPGDTDP1FFAR1AOC3KMT2A | |
| SCHEMBL903669 | 0.74 | HPGD (0.46) | HPGDTDP1FFAR1AOC3KMT2A | |
| SCHEMBL2485604 | 0.71 | SLC6A2 (0.50) | HPGDTDP1KMT2ANPSR1LMNA | |
| SCHEMBL13388983 | 0.71 | AOC3 (0.42) | TDP1AOC3KMT2AHDAC3HDAC4 | |
| SCHEMBL25169591 | 0.70 | TXNRD1 (0.36) | HPGDTDP1AOC3KMT2ANPSR1 | |
| SCHEMBL25169590 | 0.70 | TXNRD1 (0.36) | HPGDTDP1AOC3KMT2ANPSR1 | |
| Hydrochloric Acid SCHEMBL1695675 | 0.70 | SLC6A2 (0.49) | HPGDTDP1KMT2ANPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1611129-B1 | CYCLIC SULFAMIDES FOR INHIBITION OF GAMMA-SECRETASE | MERCK SHARP & DOHME (GB) | 2009-09-30 | — | — | EP | disclosed |
| EP-1611129-B1 | CYCLIC SULFAMIDES FOR INHIBITION OF GAMMA-SECRETASE | MERCK SHARP & DOHME (GB) | 2009-09-30 | — | — | EP | disclosed |
| US-7427621-B2 | Cyclic sulfamides for inhibition of gamma-secretase | MERCK SHARP & DOHME LIMITED (GB) | 2008-09-23 | — | — | US | disclosed |
| US-7427621-B2 | Cyclic sulfamides for inhibition of gamma-secretase | MERCK SHARP & DOHME LIMITED (GB) | 2008-09-23 | — | — | US | disclosed |
| US-7427621-B2 | Cyclic sulfamides for inhibition of gamma-secretase | MERCK SHARP & DOHME LIMITED (GB) | 2008-09-23 | — | — | US | disclosed |
| US-20060135570-A1 | Cyclic sulfamides for inhibiton of gamma-secretase | MERCK SHARP & DOHME LTD. (GB) | 2006-06-22 | — | — | US | disclosed |
| EP-1611129-A1 | CYCLIC SULFAMIDES FOR INHIBITION OF GAMMA-SECRETASE | MERCK SHARP & DOHME LTD. (GB) | 2006-01-04 | — | — | EP | disclosed |
| WO-2004039800-A1 | CYCLIC SULFAMIDES FOR INHIBITION OF GAMMA-SECRETASE | MERCK SHARP & DOHME LIMITED (GB) | 2004-05-13 | — | — | WO | disclosed |
| WO-2004039800-A1 | CYCLIC SULFAMIDES FOR INHIBITION OF GAMMA-SECRETASE | MERCK SHARP & DOHME LIMITED (GB) | 2004-05-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135570-A1 | Cyclic sulfamides for inhibiton of gamma-secretase | BACE1, PSEN1, BACE2 | HPGD 2005/4885TDP1 1617/4885FFAR1 3849/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.