Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLKB1 | P03952 | 13/20 | 0.54 |
| ▸ | F10 | P00742 | 4/20 | 0.47 |
| ▸ | F9 | P00740 | 2/20 | 0.47 |
| ▸ | CARM1 | Q86X55 | 3/20 | 0.47 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.45 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3832713 | 0.84 | F10 (0.68) | KLKB1F10F9PRSS1PRSS2 | |
| SCHEMBL21100632 | 0.80 | KLKB1 (0.64) | KLKB1F10CARM1 | |
| SCHEMBL3831242 | 0.80 | F10 (0.71) | KLKB1F10F9CARM1PRSS1 | |
| SCHEMBL3834889 | 0.79 | KLKB1 (0.61) | KLKB1CARM1PRSS1PRSS2PRSS3 | |
| SCHEMBL3829467 | 0.79 | KLKB1 (0.61) | KLKB1F10F9CARM1PRSS1 | |
| SCHEMBL21507501 | 0.79 | CARM1 (0.62) | KLKB1CARM1PRSS1PRSS2PRSS3 | |
| SCHEMBL18604707 | 0.78 | KLKB1 (0.66) | KLKB1CARM1 | |
| SCHEMBL29826481 | 0.78 | KLKB1 (0.66) | KLKB1CARM1 | |
| SCHEMBL7410815 | 0.77 | KLKB1 (0.55) | KLKB1F10F9CARM1PRSS1 | |
| SCHEMBL17065016 | 0.77 | KLKB1 (0.58) | KLKB1CARM1PRSS1PRSS2PRSS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946508-B1 | NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2009-09-23 | — | — | EP | disclosed |
| US-6548512-B1 | Pyrazole derivatives such as 1-(3-amidinophenyl)-3-methyl-2-((5-(2'-aminosulfonylphenyl-1-yl)pyrimidin-2 -yl)aminocarbonyl)pyrazole; treating thromboembolic disorders | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-04-15 | — | — | US | disclosed |
| US-6020357-A | CARDIOVASCULAR DISORDERS; ANTCOAGULANTS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-02-01 | — | — | US | disclosed |
| EP-0946508-A1 | NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS | Du Pont Pharmaceuticals Company (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998028269-A1 | NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-07-02 | — | — | WO | disclosed |