Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 10/20 | 0.51 |
| ▸ | F2 | P00734 | 5/20 | 0.51 |
| ▸ | KLKB1 | P03952 | 8/20 | 0.47 |
| ▸ | F9 | P00740 | 3/20 | 0.44 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3829648 | 0.89 | KLKB1 (0.62) | F10F2KLKB1F9 | |
| SCHEMBL3836097 | 0.85 | KLKB1 (0.63) | F10F2KLKB1F9 | |
| SCHEMBL3829580 | 0.85 | F10 (0.52) | F10F2KLKB1F9 | |
| SCHEMBL27544240 | 0.79 | F10 (0.62) | F10F2KLKB1F9 | |
| SCHEMBL7071556 | 0.71 | F10 (0.70) | F10F2F9 | |
| SCHEMBL12361486 | 0.69 | KLKB1 (0.75) | F10KLKB1F9CARM1 | |
| SCHEMBL27519329 | 0.69 | F10 (0.74) | F10F2KLKB1 | |
| SCHEMBL27518352 | 0.68 | F10 (0.76) | F10F2KLKB1F9 | |
| SCHEMBL12589579 | 0.68 | F10 (1.00) | F10F2F9 | |
| SCHEMBL28111093 | 0.68 | KLKB1 (0.72) | KLKB1CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946508-B1 | NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS | BRISTOL MYERS SQUIBB PHARMA CO (US) | 2009-09-23 | — | — | EP | disclosed |
| US-6548512-B1 | Pyrazole derivatives such as 1-(3-amidinophenyl)-3-methyl-2-((5-(2'-aminosulfonylphenyl-1-yl)pyrimidin-2 -yl)aminocarbonyl)pyrazole; treating thromboembolic disorders | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2003-04-15 | — | — | US | disclosed |
| US-6020357-A | CARDIOVASCULAR DISORDERS; ANTCOAGULANTS | DUPONT PHARMACEUTICALS COMPANY (US) | 2000-02-01 | — | — | US | disclosed |
| EP-0946508-A1 | NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS | Du Pont Pharmaceuticals Company (US) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998028269-A1 | NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS | DU PONT PHARMACEUTICALS COMPANY (US) | 1998-07-02 | — | — | WO | disclosed |