SCHEMBL3836097

SCHEMBL3836097

Cc1nccn1-c1ccc(NC(=O)c2cc(C(F)(F)F)nn2-c2cccc(CN)c2)cc1F

nearest known ligand 0.63

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
KLKB1 P03952 16/20 0.63
F2 P00734 5/20 0.56
F10 P00742 5/20 0.56
PRSS1 P07477 5/20 0.56
PRSS2 P07478 5/20 0.56
PRSS3 P35030 5/20 0.56
F9 P00740 2/20 0.55
PROC P04070 2/20 0.55
KLK1 P06870 1/20 0.55
CFH P08603 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL3829648 0.97 KLKB1 (0.62) KLKB1F2F10PRSS1PRSS2
SCHEMBL3829580 0.86 F10 (0.52) KLKB1F2F10PRSS1PRSS2
Trifluoroacetic Acid SCHEMBL3834875 0.85 F10 (0.51) KLKB1F2F10F9
SCHEMBL27544240 0.81 F10 (0.62) KLKB1F2F10F9PROC
SCHEMBL3833474 0.77 KLKB1 (0.66) KLKB1F2F10PRSS1PRSS2
SCHEMBL30415357 0.76 KLKB1 (0.87) KLKB1
SCHEMBL18604685 0.76 KLKB1 (0.87) KLKB1
SCHEMBL31067520 0.76 KLKB1 (0.87) KLKB1
SCHEMBL17064482 0.76 KLKB1 (0.87) KLKB1
SCHEMBL28111188 0.76 KLKB1 (0.83) KLKB1F2F10PRSS1PRSS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0946508-B1 NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS BRISTOL MYERS SQUIBB PHARMA CO (US) 2009-09-23 EP claimed
US-6020357-A CARDIOVASCULAR DISORDERS; ANTCOAGULANTS DUPONT PHARMACEUTICALS COMPANY (US) 2000-02-01 US claimed
EP-0946508-A1 NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS Du Pont Pharmaceuticals Company (US) 1999-10-06 EP claimed
WO-1998028269-A1 NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS DU PONT PHARMACEUTICALS COMPANY (US) 1998-07-02 WO claimed
EP-0946508-B1 NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS BRISTOL MYERS SQUIBB PHARMA CO (US) 2009-09-23 EP disclosed
US-6548512-B1 Pyrazole derivatives such as 1-(3-amidinophenyl)-3-methyl-2-((5-(2'-aminosulfonylphenyl-1-yl)pyrimidin-2 -yl)aminocarbonyl)pyrazole; treating thromboembolic disorders BRISTOL-MYERS SQUIBB PHARMA COMPANY 2003-04-15 US disclosed
US-6020357-A CARDIOVASCULAR DISORDERS; ANTCOAGULANTS DUPONT PHARMACEUTICALS COMPANY (US) 2000-02-01 US disclosed
EP-0946508-A1 NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS Du Pont Pharmaceuticals Company (US) 1999-10-06 EP disclosed
WO-1998028269-A1 NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS DU PONT PHARMACEUTICALS COMPANY (US) 1998-07-02 WO disclosed