Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 1/20 | 0.38 |
| ▸ | CLK3 | P49761 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 15/20 | 0.36 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3837040 | 0.91 | NR1H2 (0.41) | NR1H2NR1H3 | |
| SCHEMBL3835114 | 0.89 | NR1H2 (0.40) | NR1H2NR1H3 | |
| SCHEMBL3835772 | 0.88 | NR1H2 (0.41) | NR1H2NR1H3 | |
| SCHEMBL3839736 | 0.88 | TTK (0.37) | CLK2CLK3DYRK1ANR1H2NR1H3 | |
| SCHEMBL3841145 | 0.88 | NR1H2 (0.43) | NR1H2NR1H3 | |
| SCHEMBL3842078 | 0.87 | NR1H2 (0.36) | NR1H2NR1H3PARP1 | |
| SCHEMBL3835120 | 0.87 | NR1H2 (0.39) | NR1H2NR1H3PARP1 | |
| SCHEMBL3837852 | 0.87 | NR1H2 (0.41) | NR1H2NR1H3PARP1 | |
| SCHEMBL3835025 | 0.86 | PARP1 (0.40) | NR1H2NR1H3PARP1 | |
| SCHEMBL3835632 | 0.86 | PARP1 (0.40) | NR1H2NR1H3PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |