Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 8/20 | 0.36 |
| ▸ | WNT1 | P04628 | 3/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.36 |
| ▸ | CLK2 | P49760 | 1/20 | 0.36 |
| ▸ | CLK3 | P49761 | 1/20 | 0.36 |
| ▸ | CCNK | O75909 | 1/20 | 0.35 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3835772 | 0.92 | NR1H2 (0.41) | NR1H2NR1H3 | |
| SCHEMBL3842078 | 0.91 | NR1H2 (0.36) | NR1H2NR1H3PARP1 | |
| SCHEMBL3839371 | 0.89 | CHEK1 (0.42) | NR1H2NR1H3CHEK1PARP1 | |
| SCHEMBL3837598 | 0.88 | NR1H2 (0.38) | NR1H2NR1H3 | |
| SCHEMBL3837852 | 0.88 | NR1H2 (0.41) | NR1H2NR1H3PARP1 | |
| SCHEMBL3835637 | 0.88 | CLK2 (0.38) | NR1H2DYRK1ACLK2CLK3TBK1 | |
| SCHEMBL3835632 | 0.87 | PARP1 (0.40) | NR1H2NR1H3PARP1 | |
| SCHEMBL3835025 | 0.87 | PARP1 (0.40) | NR1H2NR1H3PARP1 | |
| SCHEMBL3835114 | 0.87 | NR1H2 (0.40) | NR1H2NR1H3 | |
| SCHEMBL3837040 | 0.86 | NR1H2 (0.41) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |