Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL788672 | 0.83 | EGFR (0.48) | KDM4EMAPK1SMN1; SMN2EGFRERBB2 | |
| SCHEMBL4137771 | 0.73 | EGFR (0.47) | KDM4EMAPK1SMN1; SMN2EGFRERBB2 | |
| SCHEMBL68412 | 0.73 | L3MBTL1 (0.50) | MAPK1SMN1; SMN2ALDH1A1MAPTMEN1 | |
| Ethyl Benzoate SCHEMBL27653361 | 0.73 | SMN1; SMN2 (0.47) | MAPK1SMN1; SMN2ALDH1A1MAPTMEN1 | |
| Fluoride SCHEMBL27313204 | 0.71 | MAPK1 (0.55) | KDM4EMAPK1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL18945510 | 0.71 | EPHX2 (0.46) | MAPK1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL28232439 | 0.70 | EGFR (0.48) | EGFRERBB2HCAR2NPC1 | |
| SCHEMBL20241752 | 0.70 | GLA (0.53) | KDM4EMAPK1EGFRERBB2ALDH1A1 | |
| SCHEMBL7637921 | 0.70 | EGFR (0.49) | EGFRERBB2ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL1511063 | 0.70 | CYP4F2 (0.55) | EGFRL3MBTL1TDP1THRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1847524-B1 | Terphenyl derivatives for treatment of Alzheimer's disease | CELLZOME LTD (GB) | 2009-10-14 | — | — | EP | disclosed |
| EP-1847524-A1 | Terphenyl derivatives for treatment of Alzheimer's disease | Cellzome (UK) Ltd. (GB) | 2007-10-24 | — | — | EP | disclosed |