Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 11/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 2/20 | 0.34 |
| ▸ | ATRIP | Q8WXE1 | 2/20 | 0.34 |
| ▸ | GPR4 | P46093 | 1/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3863205 | 0.92 | HRH3 (0.39) | NR1H2AURKAKDRNR1H3 | |
| SCHEMBL3837061 | 0.89 | NTRK1 (0.36) | NR1H2PKMATRATRIPNR1H3 | |
| SCHEMBL3855204 | 0.85 | ALDH1A1 (0.35) | NR1H2ALDH1A1MEN1NPC1TP53 | |
| SCHEMBL3839112 | 0.85 | NR1H2 (0.38) | NR1H2NR1H3 | |
| SCHEMBL3834957 | 0.83 | ATR (0.38) | NR1H2ATRATRIPNR1H3 | |
| SCHEMBL3859943 | 0.82 | NR1H2 (0.35) | NR1H2ATRATRIPNR1H3 | |
| SCHEMBL3840220 | 0.82 | ATR (0.35) | NR1H2AURKAKDRATRATRIP | |
| SCHEMBL3166857 | 0.82 | NR1H2 (0.37) | NR1H2ALDH1A1KDRPKMATR | |
| SCHEMBL3043824 | 0.82 | NR1H2 (0.38) | NR1H2ALDH1A1GAAKDRPKM | |
| SCHEMBL3835632 | 0.81 | PARP1 (0.40) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |