Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.33 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 2/20 | 0.32 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3837075 | 0.92 | GPR119 (0.35) | GPR119MCHR1NR1H2KDRPARP1 | |
| SCHEMBL3835247 | 0.92 | PARP1 (0.37) | GPR119NR1H2PARP1NR1H3 | |
| SCHEMBL3839027 | 0.91 | PARP1 (0.37) | GPR119MCHR1NR1H2PARP1NR1H3 | |
| SCHEMBL3840818 | 0.87 | PARP1 (0.40) | NR1H2PARP1NR1H3 | |
| SCHEMBL3837004 | 0.87 | ATR (0.38) | GPR119NR1H2PARP1NR1H3 | |
| SCHEMBL3834991 | 0.85 | HRH3 (0.39) | GPR119MCHR1NR1H2PARP1NR1H3 | |
| SCHEMBL3840823 | 0.85 | NR1H2 (0.33) | GPR119NR1H2PARP1NR1H3 | |
| SCHEMBL3839726 | 0.85 | PARP1 (0.36) | MCHR1NR1H2PARP1NR1H3 | |
| SCHEMBL3835632 | 0.85 | PARP1 (0.40) | NR1H2PARP1NR1H3 | |
| SCHEMBL3835025 | 0.85 | PARP1 (0.40) | NR1H2PARP1NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |