Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | PLK1 | P53350 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 3/20 | 0.36 |
| ▸ | EDNRB | P24530 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | ACE | P12821 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1626972 | 0.82 | ALDH1A1 (0.39) | KIF11EPHX2NR1H4PLK1TAS1R3 | |
| SCHEMBL1626673 | 0.78 | PLK1 (0.47) | KIF11EPHX2NR1H4PLK1TAS1R3 | |
| SCHEMBL1626435 | 0.76 | PLK1 (0.47) | KIF11EPHX2NR1H4PLK1AKR1C3 | |
| SCHEMBL1626676 | 0.74 | CNR2 (0.46) | KIF11EPHX2NR1H4PLK1TAS1R3 | |
| SCHEMBL12260669 | 0.69 | SMN1; SMN2 (0.48) | KIF11EPHX2NR1H4PLK1AKR1C3 | |
| SCHEMBL6898376 | 0.66 | MAPT (0.52) | ALDH1A1TSHRSMN1; SMN2LMNAMAPT | |
| SCHEMBL14269723 | 0.66 | ALDH1A1 (0.51) | KIF11EPHX2NR1H4PLK1AKR1C3 | |
| SCHEMBL28044958 | 0.65 | MAPT (0.50) | ALDH1A1ELANETSHRMAPK1MAPT | |
| Hydrochloric Acid SCHEMBL28209912 | 0.65 | KMT2A (0.50) | ALDH1A1TSHRSMN1; SMN2MAPTKMT2A | |
| SCHEMBL15023275 | 0.64 | SMN1; SMN2 (0.56) | ALDH1A1TSHRMAPK1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111399-A2 | NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF | Amgen Inc. (US) | 2009-10-28 | — | — | EP | disclosed |
| WO-2008076427-A2 | NAPHTHALENONE COMPOUNDS EXHIBITING PROLYL HYDROXYLASE INHIBITORY ACTIVITY, COMPOSITIONS, AND USES THEREOF | AMGEN INC. (US) | 2008-06-26 | — | — | WO | disclosed |