Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.66 |
| ▸ | DRD3 | P35462 | 3/20 | 0.66 |
| ▸ | DRD4 | P21917 | 1/20 | 0.66 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1840932 | 0.80 | DRD2 (1.00) | DRD2DRD3DRD4 | |
| SCHEMBL1842073 | 0.80 | DRD2 (1.00) | DRD2DRD3DRD4 | |
| SCHEMBL12661863 | 0.80 | DRD2 (1.00) | DRD2DRD3DRD4 | |
| SCHEMBL5200428 | 0.80 | DRD2 (0.73) | DRD2DRD3DRD4 | |
| SCHEMBL5188361 | 0.80 | DRD2 (1.00) | DRD2DRD3DRD4 | |
| Water SCHEMBL1841645 | 0.79 | DRD2 (0.97) | DRD2DRD3DRD4 | |
| SCHEMBL2080862 | 0.77 | DRD3 (0.60) | DRD2DRD3DRD4 | |
| SCHEMBL24614025 | 0.76 | DRD2 (1.00) | DRD2DRD3DRD4 | |
| SCHEMBL22533994 | 0.76 | DRD2 (1.00) | DRD2DRD3DRD4 | |
| SCHEMBL2081048 | 0.75 | DRD2 (0.54) | DRD2DRD3DRD4CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104503-A1 | MORPHOLINE DOPAMINE AGONISTS FOR THE TREATMENT OF PAIN | Pfizer Limited (GB) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008087512-A1 | MORPHOLINE DOPAMINE AGONISTS FOR THE TREATMENT OF PAIN | PFIZER LIMITED (GB) | 2008-07-24 | — | — | WO | disclosed |