Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.37 |
| ▸ | AURKA | O14965 | 3/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.33 |
| ▸ | FLT3 | P36888 | 2/20 | 0.33 |
| ▸ | GSK3B | P49841 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | TDP2 | O95551 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.32 |
| ▸ | MET | P08581 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31158957 | 1.00 | GRM5 (0.37) | GRM5AURKACLK4NTRK1FLT3 | |
| SCHEMBL23089173 | 0.81 | GRM5 (0.37) | GRM5AURKACLK4NTRK1FLT3 | |
| SCHEMBL23364331 | 0.81 | MKNK2 (0.43) | GRM5AURKACLK4NTRK1FLT3 | |
| SCHEMBL3840001 | 0.79 | PARP10 (0.36) | AURKACLK4NTRK1FLT3GSK3B | |
| SCHEMBL3835512 | 0.79 | KDR (0.41) | AURKACLK4NTRK1FLT3GSK3B | |
| SCHEMBL3837295 | 0.78 | AURKA (0.37) | AURKACLK4NTRK1FLT3GSK3B | |
| SCHEMBL3835742 | 0.78 | AURKA (0.37) | AURKACLK4NTRK1FLT3GSK3B | |
| SCHEMBL31392277 | 0.78 | GRM5 (0.37) | GRM5AURKACLK4NTRK1FLT3 | |
| SCHEMBL31159152 | 0.75 | GRM5 (0.36) | GRM5AURKACLK4NTRK1FLT3 | |
| SCHEMBL3840782 | 0.75 | AURKA (0.32) | AURKACA12CA9KDRTDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |