Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.36 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
| ▸ | CA9 | Q16790 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 3/20 | 0.34 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
| ▸ | TDP2 | O95551 | 3/20 | 0.33 |
| ▸ | PARP1 | P09874 | 3/20 | 0.33 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.32 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.32 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | CLK3 | P49761 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | MET | P08581 | 1/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3835512 | 0.81 | KDR (0.41) | PARP10CA12CA9AURKAKDR | |
| SCHEMBL2026201 | 0.79 | PIK3CD (0.41) | PARP10PARP11KMT2ACA12CA9 | |
| SCHEMBL12951697 | 0.79 | KDR (0.37) | PARP10PARP11KMT2ACA12CA9 | |
| SCHEMBL1476404 | 0.79 | MKNK2 (0.41) | PARP10PARP11KMT2ACA12CA9 | |
| SCHEMBL3835742 | 0.79 | AURKA (0.37) | KMT2ACA12CA9AURKAKDR | |
| SCHEMBL3837295 | 0.79 | AURKA (0.37) | CA12CA9AURKAKDRTDP2 | |
| SCHEMBL3836901 | 0.79 | GRM5 (0.37) | PARP10CA12CA9AURKAKDR | |
| SCHEMBL31158957 | 0.79 | GRM5 (0.37) | PARP10CA12CA9AURKAKDR | |
| SCHEMBL3840782 | 0.77 | AURKA (0.32) | CA12CA9AURKAKDRTDP2 | |
| SCHEMBL3837257 | 0.75 | PDE3B (0.43) | AURKAKDRMAP3K9MAP3K11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |