Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.32 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.31 |
| ▸ | DRD1 | P21728 | 1/20 | 0.31 |
| ▸ | KIF11 | P52732 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3836548 | 1.00 | TAAR1 (0.38) | TAAR1MAPK14OPRM1OPRL1SLC6A4 | |
| SCHEMBL3836805 | 1.00 | TAAR1 (0.38) | TAAR1MAPK14OPRM1OPRL1SLC6A4 | |
| SCHEMBL3839037 | 0.99 | TAAR1 (0.38) | TAAR1MAPK14OPRM1OPRL1SLC6A4 | |
| SCHEMBL3843230 | 0.96 | TAAR1 (0.38) | TAAR1MAPK14OPRM1OPRL1GRM2 | |
| SCHEMBL1710521 | 0.78 | SLC6A4 (0.33) | SLC6A4 | |
| SCHEMBL1710534 | 0.77 | KDM4E (0.34) | SLC6A4SMN1; SMN2 | |
| SCHEMBL1710757 | 0.76 | SLC6A4 (0.32) | SLC6A4 | |
| SCHEMBL611370 | 0.76 | MAPK14 (0.40) | TAAR1MAPK14OPRM1OPRL1DRD2 | |
| SCHEMBL610832 | 0.76 | MAPK14 (0.40) | TAAR1MAPK14OPRM1OPRL1DRD2 | |
| SCHEMBL611797 | 0.76 | MAPK14 (0.40) | TAAR1MAPK14OPRM1OPRL1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111223-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-10-28 | — | — | EP | disclosed |
| WO-2009058216-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-05-07 | — | — | WO | disclosed |