Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | KIF11 | P52732 | 2/20 | 0.32 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.30 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.30 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3839037 | 0.97 | TAAR1 (0.38) | TAAR1MAPK14OPRM1OPRL1DRD2 | |
| SCHEMBL3836805 | 0.96 | TAAR1 (0.38) | TAAR1MAPK14OPRM1OPRL1DRD2 | |
| SCHEMBL3836993 | 0.96 | TAAR1 (0.38) | TAAR1MAPK14OPRM1OPRL1DRD2 | |
| SCHEMBL3836548 | 0.96 | TAAR1 (0.38) | TAAR1MAPK14OPRM1OPRL1DRD2 | |
| SCHEMBL1710757 | 0.75 | SLC6A4 (0.32) | — | |
| SCHEMBL1725244 | 0.74 | KDM4E (0.35) | — | |
| SCHEMBL1710521 | 0.74 | SLC6A4 (0.33) | — | |
| SCHEMBL1710534 | 0.73 | KDM4E (0.34) | — | |
| SCHEMBL611371 | 0.73 | MAPK14 (0.41) | TAAR1MAPK14OPRM1OPRL1DRD2 | |
| SCHEMBL3837584 | 0.72 | AURKA (0.43) | TAAR1KIF11SMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2111223-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-10-28 | — | — | EP | disclosed |
| WO-2009058216-A1 | AMINE DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA, INC. (US) | 2009-05-07 | — | — | WO | disclosed |