Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 13/20 | 0.56 |
| ▸ | CCND1 | P24385 | 10/20 | 0.56 |
| ▸ | CCND2 | P30279 | 8/20 | 0.56 |
| ▸ | CCND3 | P30281 | 8/20 | 0.56 |
| ▸ | CDK1 | P06493 | 10/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 8/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.56 |
| ▸ | CDK2 | P24941 | 6/20 | 0.56 |
| ▸ | CCNE2 | O96020 | 5/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.56 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 3/20 | 0.56 |
| ▸ | CCNB3 | Q8WWL7 | 3/20 | 0.56 |
| ▸ | AURKA | O14965 | 9/20 | 0.55 |
| ▸ | INSR | P06213 | 1/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 1/20 | 0.55 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | FLT4 | P35916 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12639318 | 0.91 | CDK4 (0.67) | CDK4CCND1CCND2CCND3CDK1 | |
| SCHEMBL12672279 | 0.91 | CDK4 (0.53) | CDK4CCND1CCND2CCND3CDK1 | |
| SCHEMBL12639370 | 0.88 | CDK1 (0.56) | CDK4CCND1CCND2CCND3CDK1 | |
| SCHEMBL12639365 | 0.88 | CDK4 (0.54) | CDK4CCND1CCND2CCND3CDK1 | |
| SCHEMBL1355312 | 0.88 | CDK4 (0.67) | CDK4CCND1CCND2CCND3CDK1 | |
| SCHEMBL1355734 | 0.86 | CDK4 (0.69) | CDK4CCND1CCND2CCND3CDK1 | |
| SCHEMBL12639344 | 0.86 | CDK4 (0.69) | CDK4CCND1CCND2CCND3CDK1 | |
| SCHEMBL12639329 | 0.86 | CDK4 (0.61) | CDK4CCND1CCND2CCND3CDK1 | |
| SCHEMBL1355087 | 0.86 | CDK4 (0.73) | CDK4CCND1CCND2CCND3CDK1 | |
| SCHEMBL344014 | 0.86 | CDK4 (0.73) | CDK4CCND1CCND2CCND3CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108020-A2 | 1-H-PYRAZOLO[3,4B]PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MITOTIC KINASES | Biogen Idec MA, Inc. (US) | 2009-10-14 | — | — | EP | claimed |
| WO-2008094602-A2 | 1-H-PYRAZOLO (3,4B) PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MITOTIC KINASES | BIOGEN IDEC MA INC. (US) | 2008-08-07 | — | — | WO | claimed |