Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 8/20 | 0.69 |
| ▸ | CCND3 | P30281 | 7/20 | 0.69 |
| ▸ | CCND1 | P24385 | 7/20 | 0.69 |
| ▸ | CCND2 | P30279 | 6/20 | 0.69 |
| ▸ | CDK2 | P24941 | 5/20 | 0.57 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.57 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.57 |
| ▸ | CCNK | O75909 | 1/20 | 0.57 |
| ▸ | CDK9 | P50750 | 1/20 | 0.57 |
| ▸ | SYK | P43405 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | CDK1 | P06493 | 9/20 | 0.52 |
| ▸ | AURKA | O14965 | 7/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 7/20 | 0.52 |
| ▸ | CCNE2 | O96020 | 3/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 3/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.51 |
| ▸ | CCNB2 | O95067 | 2/20 | 0.51 |
| ▸ | CCNB3 | Q8WWL7 | 2/20 | 0.51 |
| ▸ | INSR | P06213 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12639344 | 1.00 | CDK4 (0.69) | CDK4CCND3CCND1CCND2CDK2 | |
| SCHEMBL341737 | 0.91 | EGFR (0.65) | CDK4CCND3CCND1CCND2CDK2 | |
| SCHEMBL12639355 | 0.91 | CDK4 (0.58) | CDK4CCND3CCND1CCND2CDK2 | |
| SCHEMBL12639370 | 0.88 | CDK1 (0.56) | CDK4CCND3CCND1CCND2CDK2 | |
| SCHEMBL12639318 | 0.87 | CDK4 (0.67) | CDK4CCND3CCND1CCND2CDK2 | |
| SCHEMBL14681894 | 0.87 | CDK4 (0.75) | CDK4CCND3CCND1CCND2CDK2 | |
| SCHEMBL3837154 | 0.86 | CDK4 (0.56) | CDK4CCND3CCND1CCND2CDK2 | |
| SCHEMBL11976969 | 0.86 | CDK4 (0.68) | CDK4CCND3CCND1CCND2CDK2 | |
| SCHEMBL11977226 | 0.83 | CDK4 (0.68) | CDK4CCND3CCND1CCND2CDK2 | |
| SCHEMBL12672279 | 0.83 | CDK4 (0.53) | CDK4CCND3CCND1CCND2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110281821-A9 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2011-11-17 | — | — | US | claimed |
| US-20100249067-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2010-09-30 | — | — | US | claimed |
| US-20110281821-A9 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2011-11-17 | — | — | US | disclosed |
| US-20100249067-A1 | Modulators of Mitotic Kinases | BIOGEN IDEC MA INC. (US) | 2010-09-30 | — | — | US | disclosed |
| EP-2108020-A2 | 1-H-PYRAZOLO[3,4B]PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MITOTIC KINASES | Biogen Idec MA, Inc. (US) | 2009-10-14 | — | — | EP | disclosed |
| WO-2008094602-A2 | 1-H-PYRAZOLO (3,4B) PYRIMIDINE DERIVATIVES AND THEIR USE AS MODULATORS OF MITOTIC KINASES | BIOGEN IDEC MA INC. (US) | 2008-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249067-A1 | Modulators of Mitotic Kinases | BUB1, BUB1B, CDK1 | CDK4 101/4885CCND3 196/4885CCND1 160/4885 |
| US-20110281821-A9 | Modulators of Mitotic Kinases | BUB1, BUB1B, CDK1 | CDK4 101/4885CCND3 196/4885CCND1 160/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.