Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 11/20 | 0.49 |
| ▸ | KCNQ3 | O43525 | 2/20 | 0.48 |
| ▸ | KCNQ2 | O43526 | 2/20 | 0.48 |
| ▸ | GBA1 | P04062 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1813063 | 0.88 | P2RX7 (0.51) | P2RX7KCNQ3KCNQ2GBA1NPC1 | |
| SCHEMBL1804173 | 0.87 | P2RX7 (0.51) | P2RX7KCNQ3KCNQ2GBA1NPC1 | |
| SCHEMBL1804350 | 0.85 | P2RX7 (0.65) | P2RX7KCNQ3KCNQ2GBA1NPC1 | |
| SCHEMBL5747310 | 0.84 | P2RX7 (0.54) | P2RX7KCNQ3KCNQ2GBA1 | |
| SCHEMBL1804596 | 0.84 | P2RX7 (0.54) | P2RX7KCNQ3KCNQ2GBA1 | |
| SCHEMBL3840972 | 0.84 | P2RX7 (0.54) | P2RX7KCNQ3KCNQ2GBA1ALDH1A1 | |
| SCHEMBL1801969 | 0.84 | P2RX7 (0.54) | P2RX7KCNQ3KCNQ2GBA1ALDH1A1 | |
| SCHEMBL3839569 | 0.81 | P2RX7 (0.47) | P2RX7 | |
| SCHEMBL1802502 | 0.81 | P2RX7 (0.57) | P2RX7KCNQ3KCNQ2GBA1 | |
| SCHEMBL3839589 | 0.80 | P2RX7 (0.55) | P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633717-B1 | P2X7 RECEPTOR ANTAGONISTS AND THEIR USE | ASTRAZENECA AB (SE) | 2009-10-28 | — | — | EP | claimed |