Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 15/20 | 0.56 |
| ▸ | AURKA | O14965 | 5/20 | 0.53 |
| ▸ | KDR | P35968 | 5/20 | 0.53 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CDK7 | P50613 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3839022 | 0.89 | CHEK1 (0.63) | CHEK1AURKAKDRCDK1CDK7 | |
| SCHEMBL3839156 | 0.89 | CHEK1 (0.56) | CHEK1AURKAKDRCDK1CDK7 | |
| SCHEMBL3874077 | 0.87 | CHEK1 (0.53) | CHEK1AURKAKDRCDK1CDK7 | |
| Hydrochloric Acid SCHEMBL3046615 | 0.86 | AURKA (0.68) | CHEK1AURKAKDRCDK1 | |
| Hydrochloric Acid SCHEMBL3874594 | 0.84 | CHEK1 (0.49) | CHEK1AURKAKDRCDK1 | |
| Hydrochloric Acid SCHEMBL3841238 | 0.83 | CHEK1 (0.49) | CHEK1AURKAKDRCDK1CDK7 | |
| SCHEMBL3839118 | 0.83 | CHEK1 (0.49) | CHEK1AURKAKDRCDK1CDK7 | |
| Hydrochloric Acid SCHEMBL3839798 | 0.82 | AURKA (0.48) | CHEK1AURKAKDRCDK1 | |
| SCHEMBL3839121 | 0.82 | CHEK1 (0.48) | CHEK1AURKAKDRCDK1CDK7 | |
| Hydrochloric Acid SCHEMBL3837133 | 0.81 | CHEK1 (0.47) | CHEK1AURKAKDRCDK1CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |