Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 2/20 | 0.44 |
| ▸ | KDR | P35968 | 6/20 | 0.41 |
| ▸ | RAF1 | P04049 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 6/20 | 0.41 |
| ▸ | TEK | Q02763 | 5/20 | 0.41 |
| ▸ | CSF1R | P07333 | 3/20 | 0.41 |
| ▸ | KIT | P10721 | 3/20 | 0.41 |
| ▸ | FLT4 | P35916 | 3/20 | 0.41 |
| ▸ | AURKA | O14965 | 3/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.41 |
| ▸ | LCK | P06239 | 2/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.41 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3829906 | 0.91 | RET (0.47) | RETKDRRAF1KDM4EHTT | |
| SCHEMBL3834620 | 0.90 | RET (0.39) | RETKDRRAF1BRAFFLT1 | |
| SCHEMBL3239039 | 0.90 | RET (0.40) | RETKDRRAF1BRAFFLT1 | |
| SCHEMBL3837284 | 0.89 | RET (0.44) | ALDH1A1SMN1; SMN2RETKDRRAF1 | |
| SCHEMBL3829680 | 0.87 | RET (0.50) | RETKDRRAF1KDM4EBRAF | |
| SCHEMBL3235249 | 0.84 | KDR (0.37) | RETKDRRAF1BRAFFLT3 | |
| SCHEMBL3836301 | 0.83 | KDR (0.54) | KDRRAF1BRAFFLT3 | |
| SCHEMBL3834284 | 0.81 | RET (0.43) | RETKDRRAF1BRAFFLT1 | |
| SCHEMBL3831528 | 0.81 | RET (0.61) | RETKDRFLT1TEKCSF1R | |
| SCHEMBL13790976 | 0.81 | KDM4E (0.42) | ALDH1A1SMN1; SMN2KDRRAF1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682548-B1 | PYRIDOPYRIMIDINONES FOR THE TREATMENT OF CANCER DISEASES | MERCK PATENT GMBH (DE) | 2009-09-23 | — | — | EP | claimed |