Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.73 |
| ▸ | EGFR | P00533 | 3/20 | 0.62 |
| ▸ | JAK2 | O60674 | 2/20 | 0.62 |
| ▸ | LCK | P06239 | 2/20 | 0.62 |
| ▸ | LYN | P07948 | 2/20 | 0.62 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.62 |
| ▸ | JAK1 | P23458 | 3/20 | 0.56 |
| ▸ | JAK3 | P52333 | 3/20 | 0.56 |
| ▸ | AURKA | O14965 | 2/20 | 0.47 |
| ▸ | ITK | Q08881 | 2/20 | 0.46 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.46 |
| ▸ | CDC7 | O00311 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | STK25 | O00506 | 1/20 | 0.46 |
| ▸ | CIT | O14578 | 1/20 | 0.46 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
| ▸ | GAK | O14976 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3837612 | 0.92 | SYK (0.73) | SYKEGFRJAK2LCKLYN | |
| SCHEMBL3837515 | 0.85 | SYK (1.00) | SYKEGFRJAK2LCKLYN | |
| SCHEMBL658794 | 0.84 | SYK (0.71) | SYKEGFRJAK2LCKLYN | |
| SCHEMBL2103278 | 0.82 | SYK (0.69) | SYKEGFRJAK2LCKLYN | |
| Hydrochloric Acid SCHEMBL2100858 | 0.81 | SYK (0.68) | SYKEGFRJAK2LCKLYN | |
| SCHEMBL2102411 | 0.80 | SYK (0.67) | SYKEGFRJAK2LCKLYN | |
| SCHEMBL658283 | 0.80 | SYK (0.73) | SYKEGFRJAK2LCKLYN | |
| SCHEMBL2105664 | 0.80 | SYK (0.73) | SYKEGFRJAK2LCKLYN | |
| SCHEMBL2785795 | 0.80 | SYK (0.73) | SYKEGFRJAK2LCKLYN | |
| SCHEMBL2102238 | 0.79 | SYK (0.67) | SYKEGFRJAK2LCKLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534286-B1 | METHODS OF TREATING OR PREVENTING AUTOIMMUNE DISEASES WITH 2,4-PYRIMIDINEDIAMINE COMPOUNDS | RIGEL PHARMACEUTICALS INC (US) | 2009-12-09 | — | — | EP | claimed |