Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 16/20 | 0.73 |
| ▸ | EGFR | P00533 | 2/20 | 0.73 |
| ▸ | JAK2 | O60674 | 1/20 | 0.73 |
| ▸ | LCK | P06239 | 1/20 | 0.73 |
| ▸ | LYN | P07948 | 1/20 | 0.73 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.73 |
| ▸ | JAK1 | P23458 | 2/20 | 0.57 |
| ▸ | JAK3 | P52333 | 2/20 | 0.57 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | ITK | Q08881 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3837517 | 0.92 | SYK (0.73) | SYKEGFRJAK2LCKLYN | |
| R-343 SCHEMBL2037260 | 0.85 | SYK (1.00) | SYKEGFRJAK2LCKLYN | |
| R-343 SCHEMBL31060361 | 0.85 | SYK (1.00) | SYKEGFRJAK2LCKLYN | |
| SCHEMBL657903 | 0.83 | SYK (0.71) | SYKEGFRJAK2LCKLYN | |
| SCHEMBL2104443 | 0.82 | SYK (0.64) | SYKEGFRJAK2LCKLYN | |
| SCHEMBL2101538 | 0.82 | SYK (0.69) | SYKEGFRJAK2LCKLYN | |
| SCHEMBL658283 | 0.80 | SYK (0.73) | SYKEGFRJAK2LCKLYN | |
| SCHEMBL2785795 | 0.80 | SYK (0.73) | SYKEGFRJAK2LCKLYN | |
| SCHEMBL15343489 | 0.79 | SYK (0.72) | SYKEGFRJAK2LCKLYN | |
| SCHEMBL12872816 | 0.79 | SYK (0.88) | SYKEGFRJAK2LCKLYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1534286-B1 | METHODS OF TREATING OR PREVENTING AUTOIMMUNE DISEASES WITH 2,4-PYRIMIDINEDIAMINE COMPOUNDS | RIGEL PHARMACEUTICALS INC (US) | 2009-12-09 | — | — | EP | claimed |