Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 15/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RPA1 | P27694 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3840325 | 0.96 | SIGMAR1 (0.39) | SIGMAR1GAAL3MBTL1ALDH1A1LMNA | |
| SCHEMBL3841353 | 0.91 | SIGMAR1 (0.41) | SIGMAR1GAAL3MBTL1ALDH1A1LMNA | |
| SCHEMBL240213 | 0.86 | SIGMAR1 (0.39) | SIGMAR1GAAL3MBTL1ALDH1A1LMNA | |
| SCHEMBL2526908 | 0.86 | GAA (0.40) | SIGMAR1GAAL3MBTL1ALDH1A1LMNA | |
| SCHEMBL237816 | 0.84 | SIGMAR1 (0.54) | SIGMAR1GAAL3MBTL1 | |
| SCHEMBL235600 | 0.83 | SIGMAR1 (0.55) | SIGMAR1 | |
| SCHEMBL239393 | 0.82 | SIGMAR1 (0.54) | SIGMAR1 | |
| SCHEMBL238331 | 0.82 | SIGMAR1 (0.56) | SIGMAR1 | |
| SCHEMBL240126 | 0.81 | SIGMAR1 (0.54) | SIGMAR1 | |
| SCHEMBL236046 | 0.81 | SIGMAR1 (0.55) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2097394-A1 | 1,2,4-TRIAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-09-09 | — | — | EP | claimed |
| WO-2008055932-A1 | 1,2,4-TRIAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2008-05-15 | — | — | WO | claimed |
| EP-2097394-A1 | 1,2,4-TRIAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS | Laboratorios Del. Dr. Esteve, S.A. (ES) | 2009-09-09 | — | — | EP | disclosed |
| WO-2008055932-A1 | 1,2,4-TRIAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2008-05-15 | — | — | WO | disclosed |