Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GFER | P55789 | 5/20 | 0.56 |
| ▸ | GAA | P10253 | 7/20 | 0.53 |
| ▸ | CCNE1 | P24864 | 9/20 | 0.51 |
| ▸ | CDK2 | P24941 | 9/20 | 0.51 |
| ▸ | CCNE2 | O96020 | 8/20 | 0.51 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.47 |
| ▸ | CDK9 | P50750 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 3/20 | 0.45 |
| ▸ | CCND1 | P24385 | 3/20 | 0.45 |
| ▸ | CDK7 | P50613 | 3/20 | 0.45 |
| ▸ | CCNH | P51946 | 3/20 | 0.45 |
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3842537 | 0.87 | GAA (0.62) | GFERGAACCNE1CDK2CCNE2 | |
| SCHEMBL3841286 | 0.79 | GAA (0.74) | GFERGAACCNE1CDK2CCNE2 | |
| SCHEMBL3841246 | 0.79 | GFER (0.78) | GFERGAACCNE1CDK2CCNE2 | |
| SCHEMBL3838852 | 0.77 | GFER (0.65) | GFERGAACCNE1CDK2CCNE2 | |
| SCHEMBL3843863 | 0.77 | MAPT (0.69) | GFERGAACCNE1CDK2CCNE2 | |
| SCHEMBL3837478 | 0.76 | GAA (0.64) | GFERGAACCNE1CDK2CCNE2 | |
| SCHEMBL3837950 | 0.76 | GFER (0.56) | GFERGAACCNE1CDK2CCNE2 | |
| SCHEMBL3839570 | 0.75 | MEN1 (0.67) | GFERGAACCNE1CDK2CCNE2 | |
| SCHEMBL3837079 | 0.75 | GFER (0.67) | GFERGAACCNE1CDK2CCNE2 | |
| SCHEMBL3837418 | 0.74 | GFER (0.58) | GFERGAACCNE1CDK2CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786779-B1 | 4-ARYLAZO-3,5-DIAMINO-PYRAZOLE COMPOUNDS AND USE THEREOF | INST OF EX BOTANY OF THE ASCR (CZ) | 2009-10-28 | — | — | EP | claimed |
| US-20080312238-A1 | 4-Arylazo-3,5-Diamino-Pyrazole Compounds and Use Thereof | INSTITUTE OF EXPERIMENTAL BONTANY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC, V.V.I. (CZ) | 2008-12-18 | — | — | US | claimed |
| EP-1786779-A1 | 4-ARYLAZO-3,5-DIAMINO-PYRAZOLE COMPOUNDS AND USE THEREOF | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2007-05-23 | — | — | EP | claimed |
| WO-2006024858-A1 | 4-ARYLAZO-3,5-DIAMINO-PYRAZOLE COMPOUNDS AND USE THEREOF | INSTITUTE OF EXPERIMENTAL BOTANY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 2006-03-09 | — | — | WO | claimed |
| US-8357673-B2 | 4-arylazo-3,5-diamino-pyrazole compounds and use thereof | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2013-01-22 | — | — | US | disclosed |
| EP-1786779-B1 | 4-ARYLAZO-3,5-DIAMINO-PYRAZOLE COMPOUNDS AND USE THEREOF | INST OF EX BOTANY OF THE ASCR (CZ) | 2009-10-28 | — | — | EP | disclosed |
| US-20080312238-A1 | 4-Arylazo-3,5-Diamino-Pyrazole Compounds and Use Thereof | INSTITUTE OF EXPERIMENTAL BONTANY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC, V.V.I. (CZ) | 2008-12-18 | — | — | US | disclosed |
| EP-1786779-A1 | 4-ARYLAZO-3,5-DIAMINO-PYRAZOLE COMPOUNDS AND USE THEREOF | INSTITUTE OF EXPERIMENTAL BOTANY ASCR (CZ) | 2007-05-23 | — | — | EP | disclosed |
| WO-2006024858-A1 | 4-ARYLAZO-3,5-DIAMINO-PYRAZOLE COMPOUNDS AND USE THEREOF | INSTITUTE OF EXPERIMENTAL BOTANY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 2006-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312238-A1 | 4-Arylazo-3,5-Diamino-Pyrazole Compounds and Use Thereof | CDK9, CDK3, CDK19 | GFER 3260/4885GAA 1275/4885CCNE1 93/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.