Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 5/20 | 0.53 |
| ▸ | SKP1 | P63208 | 5/20 | 0.53 |
| ▸ | SKP2 | Q13309 | 5/20 | 0.53 |
| ▸ | CNR1 | P21554 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29470195 | 1.00 | CKS1B (0.53) | CKS1BSKP1SKP2CNR1KDM4E | |
| SCHEMBL30708991 | 0.96 | KDM4E (0.50) | CKS1BSKP1SKP2CNR1KDM4E | |
| SCHEMBL30709009 | 0.87 | ADORA2A (0.46) | CKS1BSKP1SKP2CNR1KDM4E | |
| SCHEMBL30709007 | 0.87 | ADORA2A (0.46) | CKS1BSKP1SKP2CNR1KDM4E | |
| SCHEMBL31468250 | 0.86 | ADORA2A (0.53) | CKS1BSKP1SKP2CNR1KDM4E | |
| SCHEMBL4693817 | 0.83 | KDM4E (0.48) | CNR1KDM4ELMNAL3MBTL1GAA | |
| SCHEMBL23186821 | 0.82 | CKS1B (0.44) | CKS1BSKP1SKP2CNR1KDM4E | |
| SCHEMBL30709005 | 0.80 | CYP2A6 (0.42) | CKS1BSKP1SKP2CNR1KDM4E | |
| SCHEMBL5211789 | 0.79 | ADORA1 (0.42) | CNR1ADORA2ASMN1; SMN2ADORA1TP53 | |
| SCHEMBL4825069 | 0.79 | CNR1 (0.50) | CNR1KDM4EL3MBTL1ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 146 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114213343-B | Preparation and purification methods of celecoxib intermediate | 江苏豪森药业集团有限公司 | 2024-04-16 | — | — | CN | claimed |
| CN-117510465-A | 5, 6-diphenyl pyrazine-2-piperidine compound and preparation method and application thereof | 四川轻化工大学 | 2024-02-06 | — | — | CN | claimed |
| CN-117304174-A | 5, 6-diphenyl pyrazine-2-nitrogen heterocyclic compound and preparation method and application thereof | 四川轻化工大学 | 2023-12-29 | — | — | CN | claimed |
| CN-116947766-A | Preparation method of celecoxib intermediate | 普济生物科技（台州）有限公司 | 2023-10-27 | — | — | CN | claimed |
| CN-114213343-A | Preparation and purification method of celecoxib intermediate | 江苏豪森药业集团有限公司 | 2022-03-22 | — | — | CN | claimed |
| US-20190152927-A1 | NOVEL PROCESS FOR THE PREPARATION OF 2-{4-[(5,6-DIPHENYL PYRAZIN-2-YL)(ISOPROPYL)AMINO]BUTOXY}-N-(METHYLSULFONYL)ACETAMIDE AND NOVEL POLYMORPHS THEREOF | MAITHRI DRUGS PRIVATE LIMITED (IN) | 2019-05-23 | — | — | US | claimed |
| EP-3481807-A1 | NOVEL PROCESS FOR THE PREPARATION OF 2-{4-[(5,6-DIPHENYL PYRAZIN-2-YL)(ISOPROPYL)AMINO]BUTOXY}-N-(METHYLSULFONYL)ACETAMIDE AND NOVEL POLYMORPHS THEREOF | Maithri Drugs Private Limited (IN) | 2019-05-15 | — | — | EP | claimed |
| CN-107652243-A | A kind of preparation method of West pa lattice intermediate | 广东赛烽医药科技有限公司 | 2018-02-02 | — | — | CN | claimed |
| WO-2018008042-A1 | NOVEL PROCESS FOR THE PREPARATION OF 2-{4-[(5,6-DIPHENYL PYRAZIN-2-YL)(ISOPROPYL)AMINO]BUTOXY}-N-(METHYLSULFONYL)ACETAMIDE AND NOVEL POLYMORPHS THEREOF | MAITHRI DRUGS PRIVATE LIMITED (IN) | 2018-01-11 | — | — | WO | claimed |
| WO-2017029594-A1 | PROCESSES FOR PREPARATION OF SELEXIPAG AND ITS AMORPHOUS FORM | DR. REDDY'S LABORATORIES LIMITED (IN) | 2017-02-23 | — | — | WO | claimed |
| CN-105949135-A | Synthetic method of selexipag | 湖南欧亚生物有限公司 | 2016-09-21 | — | — | CN | claimed |
| WO-2025048507-A1 | ORGANIC LIGHT-EMITTING COMPOUND AND ORGANIC ELECTROLUMINESCENT DEVICE USING SAME | 솔루스첨단소재 주식회사 | 2025-03-06 | — | — | WO | disclosed |
| WO-2024142718-A1 | MANUFACTURING METHOD FOR SELEXIPAG FORM I CRYSTALS | 株式会社トクヤマ | 2024-07-04 | — | — | WO | disclosed |
| CN-118206499-A | 2,3, 5-Trisubstituted pyrazine compound and preparation method and application thereof | 郑州大学 | 2024-06-18 | — | — | CN | disclosed |
| CN-118146165-A | 2,3, 5-Trisubstituted pyrazine compound and preparation method and application thereof | 郑州大学 | 2024-06-07 | — | — | CN | disclosed |
| EP-1400518-A1 | HETEROCYCLIC COMPOUND DERIVATIVES AND MEDICINES | Nippon Shinyaku Co., Ltd. (JP) | 2004-03-24 | — | — | EP | disclosed |
| EP-1379510-A1 | ARYL AND HETEROARYL UREA CHK1 INHIBITORS FOR USE AS RADIOSENSITIZERS AND CHAMOSENSITIZERS | ICOS CORPORATION (US) | 2004-01-14 | — | — | EP | disclosed |
| US-20030069284-A1 | Compounds useful for inhibiting Chk1 | ICOS CORPORATION (A WASHINGTON CORPORATION) | 2003-04-10 | — | — | US | disclosed |
| WO-2002070494-A1 | ARYL AND HETEROARYL UREA CHK1 INHIBITORS FOR USE AS RADIOSENSITIZERS AND CHAMOSENSITIZERS | ICOS CORPORATION (US) | 2002-09-12 | — | — | WO | disclosed |
| US-4046763-A | INTERMEDIATE FOR ULTRAVIOLET LIGHT ABSORBERS | MCNEIL LABORATORIES, INCORPORATED (US) | 1977-09-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190152927-A1 | NOVEL PROCESS FOR THE PREPARATION OF 2-{4-[(5,6-DIPHENYL PYRAZIN-2-YL)(ISOPROPYL)AMINO]BUTOXY}-N-(METHYLSULFONYL)ACETAMIDE AND NOVEL POLYMORPHS THEREOF | PKD1, PKD2, CYP2S1 | CKS1B 234/4885SKP1 60/4885SKP2 313/4885 |
| US-20030069284-A1 | Compounds useful for inhibiting Chk1 | CHEK1, PCNA, CHEK2 | CKS1B 53/4885SKP1 291/4885SKP2 135/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.