SCHEMBL3837670

SCHEMBL3837670

CCc1c(C)nn(-c2cccc(C#N)c2)c1C(=O)O

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
F11 P03951 1/20 0.48
NOTUM Q6P988 2/20 0.47
GRIA2 P42262 1/20 0.43
GRIA4 P48058 1/20 0.43
PLK1 P53350 1/20 0.41
UBE2M P61081 1/20 0.41
DCUN1D1 Q96GG9 1/20 0.41
ALDH1A1 P00352 3/20 0.40
TSHR P16473 2/20 0.40
TP53 P04637 1/20 0.40
NPSR1 Q6W5P4 1/20 0.40
HSD17B10 Q99714 1/20 0.40
AR P10275 2/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
KDM4E B2RXH2 2/20 0.39
DRD2 P14416 1/20 0.38
GRM5 P41594 1/20 0.38
MAPT P10636 1/20 0.38
HTT P42858 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3831431 0.88 NOTUM (0.44) F11NOTUMGRIA2GRIA4ALDH1A1
SCHEMBL3834637 0.85 F11 (0.52) F11NOTUMPLK1UBE2MDCUN1D1
SCHEMBL7239764 0.76 NOTUM (0.46) F11NOTUMGRIA2GRIA4ALDH1A1
SCHEMBL2923855 0.75 ELANE (0.43) ALDH1A1TP53HSD17B10KDM4EGRM5
SCHEMBL1680141 0.74 F10 (0.53) F11NOTUMALDH1A1TSHRTP53
SCHEMBL3830277 0.74 NOTUM (0.55) F11NOTUMALDH1A1TSHRTP53
SCHEMBL3834410 0.73 ELANE (0.43) NOTUMALDH1A1HSD17B10KDM4E
Hydrochloric Acid SCHEMBL3830146 0.73 F10 (0.52) F11NOTUMALDH1A1TSHRTP53
SCHEMBL3833549 0.71 NOTUM (0.53) F11NOTUMGRIA2GRIA4ALDH1A1
SCHEMBL3834923 0.71 KMT2A (0.49) NOTUMALDH1A1TP53KDM4EMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0946508-B1 NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS BRISTOL MYERS SQUIBB PHARMA CO (US) 2009-09-23 EP disclosed
US-6548512-B1 Pyrazole derivatives such as 1-(3-amidinophenyl)-3-methyl-2-((5-(2'-aminosulfonylphenyl-1-yl)pyrimidin-2 -yl)aminocarbonyl)pyrazole; treating thromboembolic disorders BRISTOL-MYERS SQUIBB PHARMA COMPANY 2003-04-15 US disclosed
US-6020357-A CARDIOVASCULAR DISORDERS; ANTCOAGULANTS DUPONT PHARMACEUTICALS COMPANY (US) 2000-02-01 US disclosed
EP-0946508-A1 NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS Du Pont Pharmaceuticals Company (US) 1999-10-06 EP disclosed
WO-1998028269-A1 NITROGEN CONTAINING HETEROAROMATICS AS FACTOR Xa INHIBITORS DU PONT PHARMACEUTICALS COMPANY (US) 1998-07-02 WO disclosed