Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 7/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.37 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | WEE1 | P30291 | 1/20 | 0.35 |
| ▸ | PRKCA | P17252 | 2/20 | 0.33 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29222690 | 0.78 | CLK4 (0.44) | PIK3CDPIK3CBPIK3CAROCK2PIM1 | |
| SCHEMBL23735699 | 0.78 | PIK3CD (0.44) | PIK3CDPIK3CBPIK3CAROCK2PIM1 | |
| SCHEMBL1334392 | 0.78 | CLK4 (0.53) | PIK3CDPIK3CBPIK3CAROCK2PIM1 | |
| SCHEMBL29866887 | 0.78 | CLK4 (0.44) | PIK3CDPIK3CBPIK3CAROCK2PIM1 | |
| SCHEMBL27086111 | 0.74 | PIK3CD (0.44) | PIK3CDPIK3CBPIK3CAROCK2PIM1 | |
| SCHEMBL20315040 | 0.74 | HSP90AB1 (0.42) | PIK3CDPIK3CBPIK3CAROCK2PIM1 | |
| SCHEMBL30825344 | 0.74 | PIK3CD (0.44) | PIK3CDPIK3CBPIK3CAROCK2PIM1 | |
| SCHEMBL3835742 | 0.70 | AURKA (0.37) | PIK3CDPIK3CBPIK3CAROCK2PIM1 | |
| SCHEMBL4499446 | 0.69 | NTRK2 (0.56) | CLK4DYRK1BCA12CA9MST1R | |
| SCHEMBL29584703 | 0.69 | NTRK2 (0.56) | CLK4DYRK1BCA12CA9MST1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |