Arginine

SCHEMBL3840055

CC(C)N(c1cc(-c2ccc(NC(=O)c3cscn3)cc2)sc1C(=O)O)C(=O)[C@H]1CC[C@H](C)CC1.N=C(N)NCCCC(N)C(=O)O

nearest known ligand 0.49

Known targets — ChEMBL curated mechanism

The experimentally established mechanism targets of Arginine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 3)

	gene	UniProt	supporting neighbours	confidence
▸	F7	P08709	1/20	0.30

▸	F3	P13726	1/20	0.30

▸	DGAT1	O75907	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Arginine SCHEMBL2431088	1.00	F7 (0.30)	F7F3DGAT1
SCHEMBL2431094	0.91	—	—
Lysine SCHEMBL2430719	0.91	F2 (0.33)	DGAT1
Lysine SCHEMBL2430720	0.91	F2 (0.33)	DGAT1
SCHEMBL3836522	0.88	DGAT1 (0.32)	DGAT1
SCHEMBL2428165	0.87	DGAT1 (0.36)	DGAT1
SCHEMBL2428166	0.87	DGAT1 (0.36)	DGAT1
Ammonia Solution, Strong SCHEMBL2432090	0.86	DGAT1 (0.35)	DGAT1
Ammonia Solution, Strong SCHEMBL2432088	0.86	DGAT1 (0.35)	DGAT1
SCHEMBL2431789	0.86	DGAT1 (0.35)	DGAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2086966-A1	2-CARBOXY THIOPHENE DERIVATIVES AS ANTI VIRAL AGENTS	SmithKline Beecham Corporation (US)	2009-08-12	—	—	EP	disclosed
WO-2008059042-A1	2-CARBOXY THIOPHENE DERIVATIVES AS ANTI VIRAL AGENTS	SMITHKLINE BEECHAM CORPORATION (US)	2008-05-22	—	—	WO	disclosed