Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5247998 | 0.84 | SMN1; SMN2 (0.64) | SMN1; SMN2CYP1A2CYP2C19HPGDALDH1A1 | |
| SCHEMBL3532249 | 0.79 | ATR (0.54) | HPGDL3MBTL1TSHRLMNA | |
| SCHEMBL21059237 | 0.77 | CYP1A2 (0.61) | SMN1; SMN2CYP1A2CYP2C19HPGDALDH1A1 | |
| SCHEMBL11619772 | 0.77 | KDM4E (0.47) | HPGDALDH1A1L3MBTL1KDM4ETSHR | |
| SCHEMBL30681265 | 0.76 | SMN1; SMN2 (0.53) | SMN1; SMN2CYP1A2CYP2C19HPGDALDH1A1 | |
| SCHEMBL28299341 | 0.75 | TSHR (0.71) | ALDH1A1L3MBTL1KDM4ETSHRTDP1 | |
| SCHEMBL5246539 | 0.74 | TSHR (0.52) | SMN1; SMN2CYP1A2CYP2C19HPGDALDH1A1 | |
| SCHEMBL21059216 | 0.74 | CYP1A2 (0.56) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1KDM4E | |
| SCHEMBL21059229 | 0.73 | CYP1A2 (0.55) | SMN1; SMN2CYP1A2CYP2C19ALDH1A1KDM4E | |
| SCHEMBL2099201 | 0.72 | L3MBTL1 (0.43) | HPGDL3MBTL1KDM4EMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1670768-B1 | COMPOUNDS AND METHODS FOR TREATING DYSLIPIDEMIA | LILLY CO ELI (US) | 2009-09-09 | — | — | EP | disclosed |