Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.36 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.36 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.36 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3840243 | 1.00 | CHRNA7 (0.54) | CHRNA7CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL3839228 | 0.89 | CHRNA7 (0.53) | CHRNA7CHRM2CHRM1CHRM3 | |
| SCHEMBL3839223 | 0.89 | CHRNA7 (0.53) | CHRNA7CHRM2CHRM1CHRM3 | |
| SCHEMBL3843503 | 0.87 | CHRNA7 (0.51) | CHRNA7CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL3843507 | 0.87 | CHRNA7 (0.51) | CHRNA7CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL3840537 | 0.86 | CHRNA7 (0.54) | CHRNA7CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL3840541 | 0.86 | CHRNA7 (0.54) | CHRNA7CHRM2CHRM1CHRM3CHRM4 | |
| SCHEMBL1460490 | 0.85 | CHRNA7 (0.53) | CHRNA7CHRM2CHRM1 | |
| SCHEMBL1460488 | 0.85 | CHRNA7 (0.53) | CHRNA7CHRM2CHRM1 | |
| SCHEMBL3844550 | 0.85 | CHRNA7 (0.53) | CHRNA7CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236803-B2 | Aza-bicycloalkyl ethers and their use as alpha7-nAChR agonists | NOVARTIS AG (CH) | 2012-08-07 | — | — | US | claimed |
| EP-1537104-B1 | AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | claimed |
| EP-1537104-B1 | AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |