Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 14/20 | 0.58 |
| ▸ | CHRNB2 | P17787 | 13/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 13/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 2/20 | 0.41 |
| ▸ | CHRNB4 | P30926 | 12/20 | 0.41 |
| ▸ | CHRNA3 | P32297 | 12/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3840616 | 1.00 | CHRNA7 (0.58) | CHRNA7CHRNB2CHRNA4HTR3APIM1 | |
| SCHEMBL1146460 | 0.88 | CHRNA7 (0.45) | CHRNA7CHRNB2CHRNA4HTR3APIM1 | |
| SCHEMBL1146461 | 0.88 | CHRNA7 (0.45) | CHRNA7CHRNB2CHRNA4HTR3APIM1 | |
| SCHEMBL3840224 | 0.86 | CHRNA7 (0.61) | CHRNA7CHRNB2CHRNA4HTR3ACHRNB4 | |
| SCHEMBL3840226 | 0.86 | CHRNA7 (0.61) | CHRNA7CHRNB2CHRNA4HTR3ACHRNB4 | |
| SCHEMBL3843473 | 0.85 | CHRNA7 (0.60) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL3843478 | 0.85 | CHRNA7 (0.60) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL3840552 | 0.84 | CHRNA7 (0.63) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL3840554 | 0.84 | CHRNA7 (0.63) | CHRNA7CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL3844162 | 0.81 | CHRNA7 (0.63) | CHRNA7CHRNB2CHRNA4HTR3ACHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236803-B2 | Aza-bicycloalkyl ethers and their use as alpha7-nAChR agonists | NOVARTIS AG (CH) | 2012-08-07 | — | — | US | claimed |
| EP-1537104-B1 | AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | claimed |
| EP-1537104-B1 | AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | disclosed |