SCHEMBL3843473

SCHEMBL3843473

FC(F)(F)c1cccc(-c2ccc(O[C@H]3CN4CCC3CC4)nn2)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 5/20 0.60
CNR2 P34972 1/20 0.47
CHRM2 P08172 2/20 0.39
CHRM1 P11229 2/20 0.39
CHRM3 P20309 2/20 0.39
CHRM4 P08173 1/20 0.39
CHRM5 P08912 1/20 0.39
LMNA P02545 1/20 0.39
IL1B P01584 1/20 0.39
NLRP3 Q96P20 1/20 0.39
KDM4E B2RXH2 1/20 0.38
ALDH1A1 P00352 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
GABRA1 P14867 1/20 0.38
HPGD P15428 1/20 0.38
GABRG2 P18507 1/20 0.38
GABRB3 P28472 1/20 0.38
GABRA5 P31644 1/20 0.38
GABRA3 P34903 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3843478 1.00 CHRNA7 (0.60) CHRNA7CNR2CHRM2CHRM1CHRM3
SCHEMBL1145766 0.88 CHRNA7 (0.46) CHRNA7CNR2IL1BNLRP3KDM4E
SCHEMBL1145763 0.88 CHRNA7 (0.46) CHRNA7CNR2IL1BNLRP3KDM4E
SCHEMBL3840352 0.86 CHRNA7 (0.61) CHRNA7CHRM2CHRM1CHRM3CHRM4
SCHEMBL3840349 0.86 CHRNA7 (0.61) CHRNA7CHRM2CHRM1CHRM3CHRM4
SCHEMBL3840554 0.85 CHRNA7 (0.63) CHRNA7CHRM2CHRM1CHRM3CHRM4
SCHEMBL3840552 0.85 CHRNA7 (0.63) CHRNA7CHRM2CHRM1CHRM3CHRM4
SCHEMBL3840611 0.85 CHRNA7 (0.58) CHRNA7CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL3840616 0.85 CHRNA7 (0.58) CHRNA7CHRNB2CHRNB4CHRNA3CHRNA4
SCHEMBL3841492 0.83 CHRNA7 (0.63) CHRNA7CHRM2CHRM1CHRM3CHRNB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8236803-B2 Aza-bicycloalkyl ethers and their use as alpha7-nAChR agonists NOVARTIS AG (CH) 2012-08-07 US claimed
EP-1537104-B1 AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS NOVARTIS AG (CH) 2009-11-11 EP claimed
EP-1537104-B1 AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS NOVARTIS AG (CH) 2009-11-11 EP disclosed