Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 15/20 | 0.58 |
| ▸ | GPR183 | P32249 | 1/20 | 0.57 |
| ▸ | MMP13 | P45452 | 2/20 | 0.37 |
| ▸ | ACACB | O00763 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.35 |
| ▸ | GPR88 | Q9GZN0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2883402 | 0.86 | GPR119 (0.63) | GPR119GPR183KCNH2 | |
| SCHEMBL387207 | 0.84 | GPR119 (0.66) | GPR119GPR183KCNH2 | |
| SCHEMBL387122 | 0.83 | GPR119 (0.57) | GPR119GPR183MMP13KCNH2 | |
| SCHEMBL10246524 | 0.83 | GPR119 (0.58) | GPR119GPR183MMP13ACACB | |
| Trifluoroacetic Acid SCHEMBL387344 | 0.83 | GPR119 (0.58) | GPR119GPR183KCNH2 | |
| SCHEMBL870759 | 0.82 | GPR119 (0.66) | GPR119GPR183KCNH2 | |
| SCHEMBL387533 | 0.82 | GPR119 (0.65) | GPR119GPR183KCNH2 | |
| Trifluoroacetic Acid SCHEMBL388814 | 0.81 | GPR119 (0.57) | GPR119GPR183KCNH2 | |
| SCHEMBL869831 | 0.81 | GPR119 (0.64) | GPR119GPR183KCNH2 | |
| Trifluoroacetic Acid SCHEMBL388420 | 0.81 | GPR119 (0.56) | GPR119GPR183KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094683-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SmithKline Beecham Corporation (US) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008070692-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-12 | — | — | WO | disclosed |