Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 16/20 | 0.60 |
| ▸ | AURKA | O14965 | 11/20 | 0.60 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CTSV | O60911 | 1/20 | 0.37 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3840660 | 0.83 | KDR (0.62) | KDRAURKACDK1CHEK1KDM4E | |
| SCHEMBL3836059 | 0.82 | AURKA (0.54) | KDRAURKA | |
| Hydrochloric Acid SCHEMBL3837263 | 0.77 | KDR (0.54) | KDRAURKACDK1CHEK1MEN1 | |
| SCHEMBL3835222 | 0.76 | KDR (0.62) | KDRAURKACDK1CHEK1KDM4E | |
| SCHEMBL14468698 | 0.76 | KDR (0.83) | KDRAURKACDK1CTSVCTSL | |
| SCHEMBL5333071 | 0.75 | KDR (1.00) | KDRAURKACDK1CHEK1KDM4E | |
| SCHEMBL5329803 | 0.74 | KDR (0.77) | KDRAURKACDK1KDM4EMEN1 | |
| SCHEMBL3835801 | 0.71 | ELANE (0.37) | KDRAURKAALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL3839444 | 0.70 | KDR (0.60) | KDRAURKACDK1CHEK1KDM4E | |
| SCHEMBL5327042 | 0.69 | KDR (1.00) | KDRAURKACDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2108642-A1 | JAK INHIBITOR | Kyowa Hakko Kirin Co., Ltd. (JP) | 2009-10-14 | — | — | EP | disclosed |