Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 19/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3840872 | 1.00 | CRHR1 (0.43) | CRHR1AURKARPS6KB1 | |
| SCHEMBL3844530 | 1.00 | CRHR1 (0.43) | CRHR1AURKARPS6KB1 | |
| SCHEMBL3842234 | 0.89 | CRHR1 (0.46) | CRHR1AURKARPS6KB1 | |
| SCHEMBL6643610 | 0.89 | CRHR1 (0.46) | CRHR1AURKARPS6KB1 | |
| SCHEMBL6101651 | 0.89 | CRHR1 (0.38) | CRHR1 | |
| SCHEMBL6101658 | 0.89 | CRHR1 (0.38) | CRHR1 | |
| SCHEMBL6101659 | 0.89 | CRHR1 (0.38) | CRHR1 | |
| SCHEMBL6643389 | 0.88 | AURKA (0.43) | CRHR1AURKARPS6KB1 | |
| SCHEMBL3845876 | 0.88 | AURKA (0.43) | CRHR1AURKARPS6KB1 | |
| SCHEMBL3843649 | 0.86 | CRHR1 (0.43) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1446387-B1 | SUBSTITUTED ARYL 1,4-PYRAZINE DERIVATIVES | PHARMACIA & UPJOHN CO LLC (US) | 2009-11-04 | — | — | EP | disclosed |
| EP-1446387-A1 | SUBSTITUTED ARYL 1,4-PYRAZINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2004-08-18 | — | — | EP | disclosed |
| WO-2003045924-A1 | SUBSTITUTED ARYL 1,4-PYRAZINE DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 2003-06-05 | — | — | WO | disclosed |