Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 3/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3840912 | 1.00 | CHRNA7 (0.48) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL3844303 | 0.84 | CHRNA7 (0.48) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL999498 | 0.84 | CHRNA7 (0.48) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL999496 | 0.84 | CHRNA7 (0.48) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL1459611 | 0.82 | CHRNA7 (0.51) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL3839954 | 0.82 | CHRM2 (0.47) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL1459609 | 0.82 | CHRNA7 (0.51) | CHRNA7CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL372171 | 0.82 | CHRNA7 (0.67) | CHRNA7 | |
| SCHEMBL1542249 | 0.82 | CHRNA7 (0.67) | CHRNA7 | |
| SCHEMBL1542155 | 0.82 | CHRNA7 (0.67) | CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537104-B1 | AZA-BICYCLOALKYL ETHERS AND THEIR USE AS ALPHA7-NACHR AGONISTS | NOVARTIS AG (CH) | 2009-11-11 | — | — | EP | claimed |