Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR2 | P50052 | 11/20 | 0.58 |
| ▸ | AGTR1 | P30556 | 10/20 | 0.58 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.58 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.58 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL669265 | 0.94 | AGTR2 (0.52) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL7907459 | 0.90 | AGTR2 (0.47) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL3845228 | 0.90 | AGTR2 (0.57) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL1758123 | 0.90 | AGTR2 (0.64) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL669266 | 0.89 | AGTR2 (0.66) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL102109 | 0.89 | AGTR2 (0.62) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL7907742 | 0.86 | AGTR2 (0.53) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL3847580 | 0.86 | AGTR2 (0.59) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL15132375 | 0.86 | AGTR2 (0.72) | AGTR2AGTR1ABCC3ABCC4ABCB11 | |
| SCHEMBL668023 | 0.85 | AGTR2 (0.61) | AGTR2AGTR1ABCC3ABCC4ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1884240-B1 | PHARMACEUTICAL FOR PREVENTION OR TREATMENT OF BONE METABOLIC DISEASE | DAIICHI SANKYO CO LTD (JP) | 2009-11-11 | — | — | EP | claimed |